Malignant Melanoma 231, 1951.
of the Tongue.
M. D. Blackburn,
A case of primary malignant melanoma of the tongue is recorded. Primary melanoma of the oral cavity is a relatively rare lesion, 54 cases having been reported through 1941. Melanoma of the mouth shows a predilection for the maxilla, 93 Melanoma of the tongue, though per cent of reported eases, but does occur elsewhere. rare, behaves in a conventional manner. The origin of melanoma remains today as much a mystery as it was when Virchow first described this tumor ninety years ago. Many melanomas present a picture in which there is an apparent transition directly from nevus cells into melanomatous tumor tissue, whereas in other cases there are only melanoma cells without nevus cells beneath an intact overlying epithelium. In rare instances, as in the present case, a direct transition from overlying squamous epithelium into melanomatous tumor tissue is seen. In this case The brilliantly lucid and convincing papers some of the tumor cells showed “prickles.” of Masson have gone far in establishing the nevus cell as a derivative from the neurocutaneous apparatus and in fixing the melanomas as neoplasms ultimately derived from nervous tissue. This explanation seems adequate for those melanomas in which the transition from nevus cells can be demonstrated and may even be assumed for those in which melanomatous tissue lies in the subjacent tissues entirely disconnected from the overlying intact epithelium, but it falls short of explaining those histologic pictures in which the transition from squamous epithelium is clearly demonstrable and in which the tumor cells present some of the characteristics of squamous epithelial cells. The author is of the opinion that the melanoma cell may be a multipotential cell derived from the basal layer of stratified squamous epithelium.
Basal Cell Tumors: State
S. A. Wallace and J. R. Thomas.
47: 213, 1951.
The authors present a short review and discussion of the origin and characteristics of the basal cell tumors and conclude that a locally invasive epithelial neoplasm which does not spread to regional lymph nodes and which does not metastasize to distant parts cannot be called cancerous. Therefore, basal cell carcinoma is a misnomer and the term should be judiciously replaced by basal cell tumor. These growths appear to be derived from cellular elements of skin appendages rather than from the basal layer of the epidermis. Among the neoplasms derived from skin appendages, those derived from sweat Therefore, in the derivation of basal cell glands and apocrine glands are distinctive. tumors cellular elements of hair follicles become implicated.
Precancerous Lesions of the Oral Cavity; Clinical and Anatomopathologic Considerations. (Le lesioni precancerose de1 cave orale; considerazioni cliniche ed anatomopathologiche.) A. Bransi and P. Pini. Minerva med. 2: 174, 1950. Oral leucoplakia may be defined as a chronic lesion of vasically hyperkeratotic character, appearing on the mucosa in the form of plaques, with smooth, granular, or fissured surface, which pass through a fleeting erythematous phase and assume more or less delimited confines; they are white and pearly in color, and of hard, elastic consistency; they are painless, with a tendency, in a certain number of cases, to epitheliomatous degeneration. Most authors report figures ranging between 20 and 45 per cent, giving a total average of 36 per cent for the epitheliomatous degeneration of leucoplakia; but this average is much too high and the authors place it between 10 and 15 per cent on the basis of their experience with several hundreds of cases which they have followed up for years. The subjective symptoms consist of tenderness or pain, dysphagia, abnormal saliva. tion if there is an ulcerous inflammatory complication, sometimes intercurrent attacks of glossitis with fixed pain; more rarely, the clinical picture even in these phases is sub. jectively asymptomatic. These lesions occur in 3 stages, as follows: 1. Reversible erythema: vascular dilatation, epithelial proliferation, and corium infiltration.