CORRESPONDENCE lesion is also c o m p o s e d o f large deposits o f fibrous tissue and elastin. T i m intracellular process b)" which iysosontal i m p a i r m e n t leads to p r o l i f e r a t i o n o f muscle cells a n d increased synthesis o f c o n n e c t i v e tissue by tltesc cells is not known.
References 1. Ilers, I1. (;., and Van Iloof, F. (Editors): l.ysosomes and Storage Diseases. New York, Academic Press, inc., 1973. 2. Matalon, R., Cifonclli,J. A., and l)orfman, A.: L-Iduronidase in cultured human fibrohlasts and liver. Biochem. Biol)hys. Res. Conmr.. 42:34(I, 1971. 3. Dorfman, A., and Matalon, R.: The mucopolysaccharidoscs./n Stanbur)', J. E. B., Wyngaarden, J. B., and Fredericksnn, D. S. (Editors): The Metabolic Basis of htherited I)isease. New York, .McGraw-ttill Book Company, 1972, p. 1218. 4. Lindsay, S.: The cardiovascular s)stem in gargoylism. Brit. tleart ]., 12:17, 1950. 5. Peters, T. J., Takano, T., anti deDuve, C.: Sul~ellular fractionation studies on the cells isolated from normal and atherosclerotic aorta. In Ciba Foundation S)mpositnn, Atherogenesis: Initiating Factors. Amsterdam, Elsevier, 1972, p. 197.
6. Wolinsky, tl., Goldfischer, S., Schiller, B., and Kasak, I.. E.: Lysosomes in aortic smooth mttscle cells; effects of hypertension. Amer.J. Path., 73 727, 1973. 7. I.agunoff, D., Ross, R., and llanditt, E. P.: |listochemical and electron microscopic study in a case of Hurler's disease. Amer. J. Path., 41:273, 1962. 8. l'ompen, A. W. M., Ruiter, M., and Wyers, tl. J. G.: Angiokeratoma corporis diffusum (universale) Fabry, as a sign of an unknown internal disease; two autopsy reports. Acta Med. Scand., 78:231, 19 t 7. 9. Fcrrans, v . J . , tlihhs, R. G., and Burda, L. D.: T h e heart in Fabry's disease; a histod~emical and electron microscopic stud)'. Amer. J. Cardiol., 24:95, 1969. 10. llernandez, A., Jr., Marchesi, V., Goldring, D., Kissane, I., Jr., and tlargmann, A. F., Jr.: Cardiac gli'cogenosis, hemodynamic, attgiocardiographic, and electron microscopic findings-report of a case. J. Pediatrics, 68:.t00, 1966. 1 I. Weiner, .]., Lattes, R. G., Mehzcr, B. G., aud Spiro, D.: The cellular pathology of experimental hypertension. IV. Evidence for increased vascular permeability. Amer. J. Path., 54 : 187, 1969. 12. tluttner, I., More, R. J., and Rona, G.: Fine structure e~idence of specific mechanism for increased endothelial permeat~ility in experimental hypertension. Amer. J. I'ath., 61:395, 1970. 13. Wissler, R. W.: Development of the atfierosclerotic plaque. Ilosp. l'ractice, 8:61, 1973. 14. Ross, R., and Glomset, J. A.: Atherosclerosis and the arterial smooth muscle cell. Science, 180:1332, 1973.
Editorial THE SPACE PROBLEM T h e Editorial B o a r d is e x t r e m e l y gratified witlt the c o n t i n u e d g r o w t h o f ltuman Pathology. In o u r fifth }'ear o f publication we a r e experie n c i n g g r o w t h pains. T h e high cost o f paper, printing, and pnblication restricts the total t m m b e r o f pages publislted w i t h o u t a significant increase in subscription price. Inside tim back
c o v e r we Ilave m o d i f i e d tlte secion on " I n f o r m a t i o n for A u t h o r s " in o r d e r to afford g r e a t e r o p p o r t u n i t y for publication to as wide a g r o u p o f a u t h o r s as possible. T h e publication o f lengtlty p a p e r s will be limited to those cons i d e r e d to be o f unttstml m e r i t and value by the Editorial Board. Autltors a r e invited to c o m m u n i c a t e with the E d i t o r for additional information.
Correspondence BASAL L A M I N A IN GRANULAR CELL TUMORS "I'o TilE EDITOR." In the May issue C o o p e r attd G o o d m a n [ l h n n a n t'athol., 5 : 3 2 7 - 3 3 8 , 1974] described m u h i l a y e r i n g o f tile basal lami,ta in tile g r a n u l a r cell n n n o r attd n o t e d the paucity o f description o f similar findings in o t h e r nonvascular tumors. In a study o f 10 fibrosarcomas that occ u r r e d in early infancy [l'athologia E u r o p e a , 8 : 1 9 3 - 2 0 9 , 1973] we f o u n d that these tumors, in spite o f the ltistological a p p e a r a n c e o f m a l i g n a n t c h a n g e , did not give rise to metas-
rases. T w o o f tim t u m o r s were studied in de1nil by tile electron m i c r o s c o p e a n d in both m u h i p l e layers o f basal lamina-like material w e r e seen investing capillaries. Tills f e a t u r e , a l t h o u g h quite clearly seen, was not as Conspicuous as the m t t l t i l a ) e r i n g that occurs in tim g r a n u l a r cell tumors. O u r findings also sltow that soft tissue t u m o r s o t h e r than tim g r a n u l a r cell t u i n o r can display n m h i l a y c r i n g o f the basal l a m i n a in capillaries. It can be sl)eculated that the paucity o f r e p o r t s o f this feature in t t m m r s o f various kinds i-effects the lack o f a w a r e n e s s o f its existence r a t h e r than its specificity for given t u m o r types, l l o w e v e r , as s u g g e s t e d b)' G o u l d et al. l A m e r . J. Path., 66:79a, 1972], the
tlUMAN P A T H O I . O ( ; Y - - V O L U M E 6, NUMBER 5 September 1975 presence of multil:wering may well have a special significance, e.g., as an indicator of the benign or low grade malignant nature of the tumor. JOIIAN S,;~vE-S(}I)ERBERC,II, M.D. University of G6teborg G~iteborg, Sweden
cipitates in 101 tmtreated patients with Ilodgkin's d i s e a s e - 1 3 with the nfixed cell type, 11 with nodular sclerosis, and one with lymphocytic depletion. Birefringence after Congo red staining for amyloid was negative, and fluorescent antibody tests against IgG, IgA, and lgM did not show the presence of immunog[obttlins in such material, although several plasma cells showed intracytoplasmic staining with fluorescent lgG and IgM anti-
PROTEINACEOUS MATERIAL IN HODGKIN'S DISEASE
T o TIlE EDFrOR: We have recently read an interesting paper by Dorfman ~l.lld Warnke in Human Patholo9 [5:519-550, 1974] reporting the occurrence of proteinaceous precipitate in a few cases of lynq~hadenopathy simulating malignant lymphonaa. T h e authors, in agreement with Rosas-Uribe and coworkers [Cancer, 31:534-5-t2, 1973], emphasize the unknown origin of this material and believe that it has some functional as well as tOl)ographical relationship to plasma cells. In a study on proteinaceous material in I)'nq)homas we obtained some dam with regard to this subject that ma}' therefore be of interest. We found 25 instances of proteinaceous pre-
Semithin sections show a close relationship between plasma cells and proteinaceous material, and electron microscopic investigations confirm the presence of plasma cells in close proximity to dense microgranular material filling the intercellular spaces (Figs. 1, 2). T h e osmiophilic material shows an amorphous background in which scattered collagenlike fibrils are present. Sometimes the collagen-like fibrils are aggregated to form large bundles, which on the sections appear to be parallel to the plasma meml)rane of the plasma cells. Most of the cellular surface is coated with this electron dense ntaterial (the "proteinaceous material" of light microscopy). T h e plasnm cells have a.characteristically abundant rough endoplasmic reticuhnn in their cytoplasm, with flattened cisternae in
Figure I. Tile plasma cells appear to be in close relationship with protcinaceous material or sometimes within it (arrows). A Rced-Sternberg cell may be seen. (l lematoxylin, Ponceau. and fuchsin stain..x 900.)