Cardiotoxicity of anabolic steroids; animal case study of oral turinabol and methanabol

Cardiotoxicity of anabolic steroids; animal case study of oral turinabol and methanabol

Abstracts / Toxicology Letters 229S (2014) S4–S21 PS7.2-O5 Cardiotoxicity of anabolic steroids; animal case study of oral turinabol and methanabol Ch...

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Abstracts / Toxicology Letters 229S (2014) S4–S21

PS7.2-O5 Cardiotoxicity of anabolic steroids; animal case study of oral turinabol and methanabol Christina Tsitsimpikou General Chemical State Laboratory, Athens, Greece Several cardiovascular complications are associated with the use of anabolic steroids. In an animal case study, turinabol and methanabol were administered in young rabbits. The experimental scheme consisted of two oral administration periods interrupted by a wash-out period. Serial echocardiographic evaluation was performed. Oxidative stress monitoring and histopathological evaluation of heart, kidney and liver tissues were also performed.

S21

Treated animals originally showed significantly increased myocardial mass and systolic cardiac output, which normalized at the end of the wash out period. Re-administration led to increased cardiac output, at the cost though of a progressive myocardial mass reduction. A dose-dependent impaired longitudinal systolic, diastolic and global myocardial function was also observed, especially in the methanabol group. For both anabolic steroids studied, the low dose had no significant effects on oxidative stress markers monitored. Cardiac tissue in all anabolic-treated animals was characterized by hemorrhagic impregnation and organized clots, especially in the methanabol-treated animals. Fibrosis and degeneration of muscle cells with visible signs of inflammation was also observed in a dose-dependent manner. http://dx.doi.org/10.1016/j.toxlet.2014.06.108