Clinical pharmacology (4th edn)

Clinical pharmacology (4th edn)

UP.5 - Ncwemher I V82 440 increasirpgtendency to treat mild hypertension. Tltere remains a need, therefore. for novel drugs and for thosewith minimal...

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UP.5 - Ncwemher I V82

440 increasirpgtendency to treat mild hypertension. Tltere remains a need, therefore. for novel drugs and for thosewith minimal side effects and simplified dosing schedules. The second article, by Drill. gives an Progressin Drug Research. Vol. 25 overview of the numerous studies on estrogens, oral contraceptives and breast edired hy E. Jucker. Birkhuuser Verklg, ISr81. Sfi. l%.OU (viii + *W pages) cancer. The conclusion is reached that ISRN 3 7643 1179 7 estrogens are not carcinogens bnt they do develop the mammary &and to a functional This is the twenty-fifth volume in a series state that is responsiveto curcinogenic infwhich presentsreview articles on topics of luences. h is also concludtd that oral concurrent interest in phann;lceutical research. traceptives. containing an esrlogcn and The volumeshave become known as excelprogestins. are not carcinogenic and do not I:%ntworks of reference dealing concisely increase the occurrence of breast cancer in hut comprehensively with the chemical. women. pharmacologicaland clinical aspectsof the Dutton and Leakey review the pcrinatal subject being reviewed They are equally development of drug metabolizing valuable to the newcomer in the field and to enzymes. Foetal. neonatal and infant the exoert who wishes to ensure that his mammals may differ from adultsin that cerbackground of knowledge has no sipnifitain enzyme systems, especially those concant gaps. cerned with the metabolism of xenobiotics. The present volume contains seve’n may not be presentor may be in the process papers. The first. by Schier and Marxer. of being developed. This has important deals with Antihypertensive Agents implications for the perinatal use of drugs. (196Y-l%O). This is a four de force in There is a considerable lack of knowledge that, in some 120 pages, it succeeds in concerning triggers of drug-metabolizing covering 20 classesof such agentsand conenzymes in man, hence the increasedintertains I 343 references. some ds recent as est tn perinatal pharmacology. There follows a comprehensive. though 1981. Despite thns plethora of drugs or potential drugsand the undoubtedadvances inevitabl) selective, review on recent developrrents in cancer chemotherapy bl uhich have been made in the therapy of h)-penension there is still room for Jeevers. The real challense of the next decade to the oncologist is to determine improvement. About 3-W of all cases of whether solid mmours can be treated with hypertensionare wholJy or partially refracthe same degree of success as has been tive to eristing drugs; there is also an

Drug developments reviewed

Clinical introduction Clintcal Pharmacology 14th edn) hf Paul Turner and Alan Richens. Churchiil Livingsrone Medical Text, 1982. f4.50 (iii + 270 pages) ISBN 0 443 0253 I 2 This monographis a pragmatic approach to

the problems of clinical pharmacology . as encountered in medical practice. After introductory chapterson the assessmentof new drugs. factors influencing the action of

drugs, adverse effects and drug interaction. several separate chapters on particular groups nf.drugs follow. In all of thesechap ters a concise pharmacologicalintroduction precedes the pharmacotherapeutic discus sion of the group of drugs which is involved. Indications, contra-indications, side effects and relevant interactionshave been dealt with in a logical and concise ma.nner. Finally. a survey is given of the treatment of poisoning with drugs and other toxic subs tances. As a whole. the volume can be rccom mended as a most practical guide book in

achieved with leukemias and lymphomas during thk*last LOyears. Levine thcndisusses the importanttopic of the hi;lary excretion of drugs and other xenohiotlcs. Many drugs are demonstrably excreted in the bile: with others the significance oE this route is not readily apparent. ~OFexample, :II ttssessingthe importanceof enterohepatic circulation. There is still a sutprisit?p lirck of knowledge of the physiolcagyof bile formation hut studiesare in progressand these will add to the underslanding of xenobiotic excretion. FinaKy, bmrilen reviews non-invasive methA for elucidating biodvaitability mechanisms of ophthalmic drug preparations. This is a specialized. but important, topic. The particular sensitivity of the cornea and the delicacy of other structures in the eye require the use of nonconven:io:ial techniques to study the dynamics of ophthalmic drug availability. Uequdte methods have now been developed and examples of their use with pilocarjine and carbachol are given in this article. This volume maintains the high standards cf its predecessors.It will rightly find its way to the libraries of most organizations concerned with pharmaceutir,a! research and development. ROGER U BRIMBLCCNBE

drug therapy. although is is only an intrcr

duction. which remains limited to general statements.For further details the reader is bound to consult more detailed textbooks and review articles in journals. The latest edition has been thoroughly revLed to include modem topics like enkephalins. endorphinsand prostacyclin. As B textbook for undergraduate students it seems to be most s..ritable. P A. VA?.LWIETEN