Digestive functions

Digestive functions

PHYSIOLOGY Carbohydrates The main carbohydrates in the diet are sucrose, lactose, starch and cellulose (Figure 1). However, cellulose cannot be diges...

79KB Sizes 3 Downloads 49 Views

PHYSIOLOGY

Carbohydrates The main carbohydrates in the diet are sucrose, lactose, starch and cellulose (Figure 1). However, cellulose cannot be digested by humans. Starch is digested by salivary amylase (ptyalin) in the mouth and upper stomach. Ptyalin is inhibited by the low gastric pH but carbohydate digestion is continued in the small intestine by pancreatic amylase, which is more powerful than salivary amylase. Starch digestion produces maltose and short chains of glucose molecules. These, together with ingested sucrose and lactose, are broken into monosaccharides by luminal enzymes (lactase, sucrase, maltase, α-dextrinase). Fructose crosses the epithelium by facilitated diffusion, while glucose and galactose undergo secondary active transport coupled to sodium. Thus, the final products of carbohydrate digestion are all monosaccharides, which are absorbed immediately into the portal blood. Most ingested carbohydrate is digested and absorbed in the first 20% of the small intestine.

Digestive functions Adrian Thomas

Most foods cannot be absorbed in the form in which they are present but require digestion into smaller compounds that can be more easily absorbed. The basic process of digestion for the three major foods (carbohydrates, proteins, fats) is hydrolysis. Most absorption takes place in the small intestine and the absorptive surface is increased about 1000-fold by: • valvulae conniventes (mucosal folds) • villi (finger-like projections composed of epithelial cells, blood supply and a central lacteal) • microvilli (finger-like projections on the surface of epithelial cells).

Proteins Pepsin precursors (pepsinogen I and II) are activated by gastric acid and inactivated by alkali in the duodenum. Proteins are broken down to peptides in the stomach and by the major proteo-lytic pancreatic enzymes (trypsin, chymotrypsin, proelastase) in the small intestine. The peptides are further digested to free amino acids by carboxypeptidase (pancreatic), aminopeptidase and several dipeptidases (in the small intestinal brush border).D amino acids are absorbed by passive diffusion. L amino acids are actively absorbed by basic, neutral and amino acid transporters (the latter two are coupled with sodium). Dipeptides and tripeptides are absorbed by secondary active transport coupled with hydrogen ions, are hydrolysed to amino acids in the epithelial cell, then enter the blood by facilitated diffusion. Occasionally, large peptides and whole proteins are absorbed intact by endocytosis and subsequent exocytosis. This can result in severe allergic reactions and declines with age. Overall, about 50% of digested protein originates from food, 25% from digestive juices and 25% from desquamated cells.

Absorption of ions and water Sodium is actively transported from inside the epithelial cell through the basal and lateral cell walls into the paracellular spaces. Intracellular sodium is replaced by sodium from the chyme moving down the electrochemical gradient. In addition, some potassium and hydrogen ions are transported in the opposite direction in exchange for sodium ions, and some chloride ions are transported in the same direction with the sodium ions. Osmotic equilibrium is maintained by water following sodium through the epithelial membrane. In the colon, the junctions between the epithelial cells are much tighter than those in the small intestine. This prevents back diffusion of ions and water, allowing more complete absorption of sodium, especially when under the influence of aldosterone. A typical adult ingests 2000 ml/day of fluid. In addition, about 7000 ml/day of fluid is secreted into the gastrointestinal tract. Of this 9000 ml, only about 1500 ml enters the colon and only about 200 ml is lost in the stool. Similarly 5–8 g/day of sodium is ingested and 20–30 g/day is secreted into the gastrointestinal tract, but less than 0.5% is lost in the faeces. If the absorptive mechanisms are overwhelmed (e.g. in severe diarrhoea) dehydration and electrolyte depletion can occur rapidly. The epithelial cells in the ileum and large intestine can absorb chloride ions in exchange for bicarbonate ions, which are secreted. Calcium, iron, magnesium, potassium, phosphate and other ions are all actively absorbed from the small intestine.

Fats Triglycerides are the main dietary fat. They are emulsified by bile salts, lecithin and monoglycerides and the process is assisted by

Carbohydrates in food Monosaccharides

Disaccharides

Polysaccharides

Glucose

Sucrose

Starch

(glucose + fructose) Fructose

Cellulose

(glucose + galactose)

Adrian Thomas is Consultant Paediatric Gastroenterologist at Booth Hall Children’s Hospital, Manchester. He qualified from Manchester where he also completed an honours BSc in physiology. His training in paediatric gastroenterology was completed in Manchester, London, and Sydney, Australia. His research interests include inflammatory bowel disease and nutritional support.

ANAESTHESIA AND INTENSIVE CARE MEDICINE 7:2

Lactose

Galactose

Maltose

Glycogen

(glucose + glucose) 1

59

© 2006 Elsevier Ltd

PHARMACOLOGY

Reasons for malabsorption Loss of absorptive surface • Surgical resection of small intestine (short bowel syndrome) • Villous atrophy (e.g. coeliac disease) Specific enzyme defects • Lactase deficiency Motility disorders • Intestinal pseudo-obstruction Inflammatory disorders • Crohn’s disease Pancreatic insufficiency • Cystic fibrosis Hepatobiliary dysfunction • Cirrhosis 2

agitation in the small intestine. Procolipase is secreted by the pancreas and is activated by trypsin. It displaces emulsifying agents and binds lipase to the fat droplets. Lipase (lingual, gastric, pancreatic) produces free fatty acids, glycerols, monoglycerides and diglycerides. Cholesterol esters and phospholipids are hydrolysed by pancreatic cholesterol ester hydrolase and phospholipase A2 to release cholesterol, monoglycerides and fatty acids. Lipids and bile salts interact to produce micelles, which contain fatty acids, monoglycerides and cholesterol. Micelles facilitate fat digestion in three ways: • they lower the concentration of monoglycerides and free fatty acids thereby allowing triglyceride hydrolysis to continue • they move down the concentration gradient to the brush border where the lipids diffuse into the epithelial cells and are esterified • they are essential for cholesterol absorption. The bile salts are released back into the chyme and are reabsorbed in the terminal ileum, to be re-used to form micelles. Medium chain fatty acids (10–12 carbon atoms long) enter the portal blood directly. Longer fatty acids are re-esterified to triglycerides and together with cholesterol esters are coated with protein, cholesterol and phospholipid to form chylomicrons, which enter the lymphatics within the villi. Fat absorption occurs mainly in the proximal small intestine but also, to some extent, in the ileum. Overall, about 95% of ingested fat is digested and absorbed. Malabsorption The causes of malabsorption are summarized in Figure 2.

ANAESTHESIA AND INTENSIVE CARE MEDICINE 7:2



60

© 2006 Elsevier Ltd