GENETIC PREDISPOSITION TO MENINGOCOCCAL MENINGITIS

GENETIC PREDISPOSITION TO MENINGOCOCCAL MENINGITIS

501 " XBD=2282 XBD=1592 XBD=1644 XBD=1908 XBD=2166 XHG=1453 XHG=1602 XHG=1653 XHG=1919 XHG=2176 YBD=325 YHG=301>AFTER YBD=324 YBD=323 YHG=303>RELAPSE ...

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501 " XBD=2282 XBD=1592 XBD=1644 XBD=1908 XBD=2166 XHG=1453 XHG=1602 XHG=1653 XHG=1919 XHG=2176 YBD=325 YHG=301>AFTER YBD=324 YBD=323 YHG=303>RELAPSE YHG=303>OF YHG=302>TEGUMENTARY YHG=301>LEISHMANIASIS PREDISPOSITION TO MENINGOCOCCAL GENETIC

MENINGITIS |>" " XBD=1608 XBD=1771 XBD=1815 XBD=1906 XBD=2246 XBD=2348 XBD=2040 XHG=1387 XHG=1619 XHG=1782 XHG=1826 XHG=2050 XHG=2264 XHG=1917 YBD=369 YBD=368 YBD=375 YBD=373 YBD=379 YHG=348>GLUCANTIME YHG=347>THERAPY YHG=348>IN YHG=342>TRES YHG=346>(DECEMBER, YHG=341>1985) YHG=347>BRACOS " XBD=1207 XBD=249 XHG=898 XBD=320 XBD=415 XBD=458 XBD=539 XBD=584 XBD=643 XBD=812 XBD=886 XBD=945 XBD=1109 XHG=129 XHG=262 XHG=335 XHG=426 XHG=471 XHG=552 XHG=596 XHG=656 XHG=826 XHG=958YBD=437 XHG=1121 YBD=445 YBD=446 YBD=439 YBD=438 YBD=438 YBD=446 YHG=410>SIR,-It YHG=419>was YHG=410>good YHG=417>to YHG=410>find YHG=409>in YHG=408>Schifferli YHG=409>and YHG=409>Dr YHG=409>Herschel YHG=409>(Nov " XBD=1205 XBD=141 XHG=797 XBD=176 XBD=277 XBD=356 XBD=472 XBD=564 XBD=650 XBD=716 XBD=783 XBD=961 XBD=1068 XHG=98 XHG=157 XHG=193 XHG=291 XHG=371 XHG=487 XHG=579 XHG=664 XHG=731 XHG=978 XHG=1082 YBD=490 YBD=492 YBD=483 YBD=481 YBD=482 YBD=490 YBD=490 YHG=457>30, YHG=464>p YHG=454>1240) YHG=454>that YHG=455>others YHG=454>have YHG=453>read YHG=453>the YHG=453>old YHG=453>literature. YHG=454>They YHG=460>suggest " XBD=1205 XBD=155 XHG=856 XBD=219 XBD=357 XBD=416 XBD=529 XBD=621 XBD=718 XBD=800 XBD=836 XBD=976 XHG=97 XHG=175 XHG=239 XHG=378 XHG=440 XHG=551 XHG=641 XHG=739 XHG=820 XHG=996 YBD=529 YBD=527 YBD=534 YBD=526 YBD=533 YBD=534 YHG=500>that YHG=499>Dr YHG=498>George YHG=499>D. YHG=498>Heist YHG=507>may YHG=497>have YHG=497>had YHG=507>a YHG=498>genetic YHG=497>complement " XBD=1205 XBD=263 XHG=823 XBD=396 XBD=537 XBD=805 XBD=926 XBD=1001 XBD=1091 XBD=1137 XHG=97 XHG=280 XHG=412 XHG=554 XHG=940 XHG=1017 XHG=1105 XHG=1152 YBD=580 YBD=571 YBD=578 YBD=570 YBD=571 YBD=579 YBD=570 YHG=543>deficiency. YHG=542>Heist’s YHG=542>familial YHG=541>predisposition, YHG=541>which YHG=551>was YHG=541>only YHG=542>in YHG=541>the " XBD=1793 XBD=181 XHG=889 XBD=258 XBD=405 XBD=454 XBD=567 XBD=737 XBD=816 XBD=868 XBD=964 XBD=1154 XBD=1204 XHG=96 XHG=200 XHG=277 XHG=424 XHG=475 XHG=587 XHG=757 XHG=837 XHG=982 XHG=1172 YBD=617 YBD=616 YBD=624 YBD=615 YBD=614 YBD=622 YBD=624 YBD=615 YHG=588>males YHG=596>was YHG=586>claimed YHG=596>as YHG=586>being YHG=585>probably YHG=586>due YHG=592>to YHG=586>IgM YHG=586>deficiency YHG=586>in " XBD=1337 XBD=1464 XBD=1528 XBD=1659 XHG=1304 XHG=1349 XHG=1475 XHG=1540 XHG=1670 YBD=621 YBD=622 YBD=628 YHG=597>*2 YHG=596>patients YHG=596>had YHG=596>mucosal YHG=596>relapses.

" XBD=1090 XBD=1204XHG=576 XBD=191 XBD=310 XBD=460 XBD=556 XBD=766 XBD=1037 XHG=99 XHG=217 XHG=331 XHG=480 XHG=787YBD=661 XHG=1057 XHG=1110 YBD=660 YBD=659 YBD=668 YBD=658 YBD=659 YHG=624>1967.1 YHG=631>Other YHG=631>families YHG=630>with YHG=630>inheritance YHG=630>predominantly YHG=630>in YHG=630>males XBD=166 XBD=322 XBD=366 XBD=447 XBD=549 XBD=632 XBD=681 XBD=714 XBD=855 XBD=913 XBD=961 XBD=1112 XHG=922 XHG=95 XHG=181 XHG=338 XHG=383 XHG=464 XHG=572 XHG=648 XHG=697 XHG=730 XHG=978 XHG=1128 YBD=705 YBD=702 YBD=704 YBD=703 YBD=711 YBD=704 YHG=685>were YHG=675>recorded YHG=681>at YHG=675>that YHG=667>timel YHG=674>and YHG=674>in YHG=684>a YHG=667>review2 YHG=674>of YHG=675>89 YHG=675>subjects YHG=674>with " XBD=1204 XBD=1337XHG=875 XBD=1391 XBD=1558 XBD=1736 XBD=1839 XBD=1908 XBD=2001 XBD=2091 XBD=2140 XBD=2209 XBD=2284 XBD=2435 XHG=1305 XHG=1353 XHG=1408 XHG=1577 XHG=1753 XHG=1856 XHG=1924 XHG=2017 XHG=2108 XHG=2156 XHG=2228 XHG=2301 YBD=706 YBD=705 YBD=714 YHG=683>to YHG=676>be YHG=669>defined.6 YHG=675>Antibody YHG=676>titres YHG=675>fell YHG=675>with YHG=676>time YHG=676>in YHG=677>the YHG=678>125 YHG=676>patients

XBD=219 XHG=884 XBD=356 XBD=442 XBD=626 XBD=817 XBD=871 XBD=900 XBD=1033 XBD=1138 XBD=1203 XHG=95 XHG=232 XHG=369 XHG=455 XHG=638 XHG=830 XHG=914YBD=758 XHG=1046 XHG=1151 YBD=756 YBD=747 YBD=748 YBD=755 YBD=756 YBD=748 YHG=721>primary YHG=719>isolated YHG=719>IgM YHG=719>deficiency YHG=718>(presumed YHG=728>on YHG=728>a YHG=719>genetic YHG=719>basis) YHG=719>the " XBD=2434 XBD=1450 XBD=1499 XBD=1597 XBD=1634 XBD=1723 XBD=1908 XBD=2015 XBD=2118 XBD=2259 XBD=2315 XBD=2378 XHG=1305 XHG=1467 XHG=1517 XHG=1613 XHG=1654 XHG=1740 XHG=1924 XHG=2032 XHG=2134 XHG=2277 XHG=2325 XHG=2394 YBD=758 YBD=757 YBD=749 YBD=759 YBD=750 YHG=720>analysed YHG=721>in YHG=720>table YHG=727>1. YHG=720>The YHG=720>geometric YHG=729>mean YHG=721>titres YHG=721>(GMT) YHG=721>of YHG=721>the YHG=722>42 XBD=283 XHG=781 XBD=551 XBD=632 XBD=713 XBD=761 XBD=951 XBD=1159 XBD=1203 XHG=96 XHG=302 XHG=571 XHG=651 XHG=734 XHG=969 XHG=1178 YBD=794 YBD=801 YBD=791 YBD=792 YBD=792 YBD=791 YHG=764>male:female YHG=764>preponderance YHG=772>was YHG=763>4:1. YHG=762>A YHG=763>sex-linked YHG=763>inheritance YHG=762>isat " XBD=2433 XBD=1437 XBD=1529 XBD=1682 XBD=1814 XBD=1908 XBD=1977 XBD=2049 XBD=2117 XBD=2205 XBD=2259 XHG=1305 XHG=1453 XHG=1545 XHG=1697 XHG=1829 XHG=1924 XHG=1987 XHG=2065 XHG=2132 XHG=2220 XHG=2267 YBD=801 YBD=793 YBD=795 YBD=794 YBD=802 YHG=765>patients YHG=765>with YHG=764>mucosal YHG=765>disease YHG=774>were YHG=766>27.7 YHG=766>7 YHG=764>the YHG=765>time YHG=765>of YHG=765>diagnosis, " XBD=2431 XBD=234 XHG=936 XBD=340 XBD=388 XBD=440 XBD=517 XBD=572 XBD=634 XBD=797 XBD=919 XBD=974 XBD=1113 XBD=1203 XHG=94 XHG=251 XHG=356 XHG=404 XHG=458 XHG=534 XHG=583 XHG=651 XHG=814 XHG=984 XHG=1128 YBD=838 YBD=845 YBD=835 YBD=836 YBD=836 YHG=808>therefore YHG=807>likely YHG=814>to YHG=808>be YHG=816>one YHG=806>the YHG=816>common YHG=816>causes YHG=806>of YHG=807>isolated YHG=807>IgM XBD=1442 XBD=1520 XBD=1606 XBD=1670 XBD=1863 XBD=1952 XBD=2104 XBD=2312 XHG=1368 XHG=1467 XHG=1546 XHG=1632 XHG=1689 XHG=1891 XHG=2019 XHG=2130 XHG=2344 YBD=843 YBD=846 YBD=844 YBD=838 YHG=810>3 YHG=809>the YHG=809>end YHG=809>of YHG=815>treatment, YHG=809>and YHG=809>8 YHG=809>December, YHG=810>1985. at by XBD=260 XHG=852 XBD=341 XBD=463 XBD=580 XBD=730 XBD=797 XBD=833 XBD=972 XBD=1151 XBD=1208 XHG=94 XHG=281 XHG=359 XHG=482 XHG=599 XHG=750 XHG=817 XHG=991 XHG=1171 YBD=889 YBD=880 YBD=888 YBD=880 YBD=881 YHG=852>deficiency, YHG=852>and YHG=851>would YHG=852>better YHG=858>account YHG=851>for YHG=861>a YHG=851>genetic YHG=851>incidence YHG=852>of " XBD=2433 XBD=1488 XBD=1607 XBD=1670 XBD=1735 XBD=1789 XBD=1937 XBD=2028 XBD=2212 XBD=2339 XHG=1304 XHG=1503 XHG=1622 XHG=1684 XHG=1750 XHG=1804 XHG=1952 XHG=2042 XHG=2226 XHG=2353 YBD=891 YBD=890 YBD=882 YBD=884 YBD=883 YHG=853>Equivalent YHG=853>values YHG=853>for YHG=853>the YHG=854>83 YHG=854>patients YHG=853>with YHG=859>cutaneous YHG=853>lesions YHG=863>were " XBD=1208 XBD=328 XBD=564 XBD=607 XBD=669 XBD=771 XBD=890 XBD=975 XBD=1091 XBD=1161 XHG=94 XHG=339 XHG=574 XHG=618 XHG=681 XHG=783 XHG=986 XHG=1101 XHG=1171 YBD=933 YBD=924 YBD=933 YBD=925 YBD=924 YBD=933 YBD=925 YHG=896>meningococcal YHG=895>susceptibility YHG=895>in YHG=896>the YHG=896>Heist YHG=896>family YHG=895>than YHG=896>would YHG=905>any YHG=896>of XBD=1395XHG=900 XBD=1507 XBD=1588 XBD=1677 XBD=1909 XBD=2009 XBD=2220 XBD=2292 XBD=2344 XBD=2432 XHG=1304 XHG=1419 XHG=1527 XHG=1607 XHG=1698 XHG=1930 XHG=2028 XHG=2239 XHG=2311 XHG=2363 YBD=934 YBD=936 YBD=935 YBD=927 YBD=928 YHG=899>37 9, YHG=899>11 YHG=898>and YHG=899>3’ YHG=898>respectively. YHG=898>This YHG=898>progressive YHG=898>fall YHG=899>in YHG=898>titre · 0, " XBD=139 XBD=356 XBD=579 XBD=703 XBD=755 XBD=819 XBD=915 XBD=1012 XBD=1201 XHG=93 XHG=156 XHG=375 XHG=600 XHG=722 XHG=774 XHG=839 XHG=933 XHG=1031 YBD=970 YBD=977 YBD=974 YBD=969 YBD=970 YBD=970 YHG=941>the YHG=940>complement YHG=940>deficiencies, YHG=940>which YHG=950>so YHG=940>far YHG=941>have YHG=941>been YHG=941>autosomal |>" XBD=1443 XBD=1521 XBD=1696 XBD=1762 XBD=1836 XBD=1986 XBD=2049 XBD=2160 XBD=2204 XBD=2232 XBD=2354 XBD=2395 XBD=2432 XBD=1941 XHG=1303 XHG=1455 XHG=1533 XHG=1708 XHG=1775 XHG=1952 XHG=1997 XHG=2061 XHG=2172 XHG=2216 XHG=2243 XHG=2368 XHG=2407 XHG=1848 YBD=980 YBD=971 YBD=972 YBD=972 YHG=949>suggests YHG=943>that YHG=949>treatment YHG=943>has YHG=942>this YHG=943>in YHG=942>the YHG=951>group YHG=953>as YHG=952>a YHG=943>whole. YHG=943>It YHG=943>is YHG=943>effect

14.3

6.8

" YBD=1014 YHG=985>recessive. " XBD=238 XBD=1448XHG=93 XBD=1492 XBD=1556 XBD=1691 XBD=1735 XBD=1912 XBD=1956 XBD=2101 XBD=2177 XBD=2323 XBD=2368 XBD=2432 XHG=1303 XHG=1460 XHG=1505 XHG=1568 XHG=1703 XHG=1747 XHG=1924 XHG=1968 XHG=2113 XHG=2189 XHG=2336 XHG=2380 YBD=1015 YBD=1024 YBD=1016 YBD=1017 YHG=987>different YHG=993>to YHG=987>finding YHG=987>Colombia YHG=987>in YHG=987>patients YHG=987>also YHG=988>resident YHG=988>in YHG=987>the

" XBD=1046 XBD=1202 XBD=174 XBD=268 XBD=300 XBD=425 XBD=623 XBD=787 XBD=956 XHG=123 XHG=184 XHG=285 XHG=312 XHG=436 XHG=636 XHG=970 XHG=1058 YBD=1057 YBD=1058 YBD=1065 YBD=1066 YBD=1058 YBD=1066 YHG=1029>We YHG=1021>usedl YHG=1038>a YHG=1029>second YHG=1028>fluorescent YHG=1029>anti-IgM YHG=1028>antibody, YHG=1028>after YHG=1029>allowing XBD=1517XHG=799 XBD=1602 XBD=1694 XBD=1774 XBD=1876 XBD=1917 XBD=2072 XBD=2297 XBD=2432 XHG=2306 XHG=1303 XHG=1526 XHG=1615 XHG=1704 XHG=1783 XHG=1885 XHG=1927 XHG=2082 YBD=1069 YBD=1060 YBD=1061 YHG=1041>area. YHG=1032>This YHG=1041>may YHG=1032>relate YHG=1038>to YHG=1031>different YHG=1031>transmission YHG=1031>indexes " " " " " " " " " " "

XBD=138 XHG=911 XBD=372 XBD=448 XBD=520 XBD=666 XBD=729 XBD=858 XBD=901 XBD=949 XBD=1096 XBD=1138 XBD=1201 XHG=93 XHG=149 XHG=384 XHG=459 XHG=530 XHG=676 XHG=740 XHG=869 XHG=961 XHG=1106 XHG=1149 YBD=1104 YBD=1110 YBD=1109 YBD=1102 YBD=1110 YBD=1102 YHG=1074>the YHG=1073>meningococci YHG=1073>that YHG=1073>had YHG=1073>infected YHG=1073>the YHG=1073>patient YHG=1080>to YHG=1073>be YHG=1073>exposed YHG=1080>to YHG=1073>the XBD=1596 XBD=1350 XBD=1432 XBD=1506 XHG=1303 XHG=1363 XHG=1444 XHG=1518 YBD=1104 YBD=1113 YHG=1075>for YHG=1075>Lbb YHG=1076>and YHG=1076>Lbp. XBD=186 XHG=840 XBD=238 XBD=311 XBD=455 XBD=536 XBD=670 XBD=752 XBD=822 XBD=973 XBD=1051 XBD=1110 XBD=1202 XHG=93 XHG=202 XHG=249 XHG=330 XHG=475 XHG=553 XHG=687 XHG=769 XHG=991 XHG=1069 XHG=1127 YBD=1147 YBD=1145 YBD=1146 YBD=1147 YBD=1154 YBD=1146 YBD=1146 YBD=1153 YHG=1127>serum YHG=1117>of YHG=1117>patient, YHG=1118>and YHG=1117>proved YHG=1117>that YHG=1117>the YHG=1117>patients YHG=1117>had YHG=1127>no YHG=1117>IgM XBD=250 XHG=817 XBD=375 XBD=464 XBD=715 XBD=806 XBD=902 XBD=1038 XBD=1200 XHG=93 XHG=260 XHG=385 XHG=474 XHG=728 XHG=912 XHG=1048 YBD=1191 YBD=1190 YBD=1198 YBD=1191 YBD=1198 YBD=1191 YHG=1161>antibodies YHG=1161>against YHG=1161>their YHG=1162>meningococci. YHG=1162>This YHG=1171>more YHG=1161>specific YHG=1161>immunoXBD=250 XHG=861 XBD=320 XBD=422 XBD=519 XBD=639 XBD=690 XBD=842 XBD=932 XBD=1028 XBD=1062 XBD=1201 XHG=92 XHG=267 XHG=340 XHG=441 XHG=539 XHG=657 XHG=709 XHG=951 XHG=1047 XHG=1082 YBD=1243 YBD=1234 YBD=1242 YBD=1235 YBD=1235 YBD=1234 YBD=1235 YHG=1205>deficiency YHG=1206>has YHG=1206>since YHG=1206>been YHG=1206>found YHG=1206>in YHG=1206>patients YHG=1207>who YHG=1206>have YHG=1215>a YHG=1206>normal XBD=185 XHG=850 XBD=273 XBD=325 XBD=416 XBD=495 XBD=682 XBD=836 XBD=865 XBD=1059 XBD=1155 XBD=1207 XHG=92 XHG=199 XHG=288 XHG=334 XHG=433 XHG=509 XHG=697 XHG=880 XHG=1074 XHG=1169 YBD=1280 YBD=1278 YBD=1286 YBD=1287 YBD=1279 YBD=1279 YBD=1279 YHG=1259>serum YHG=1250>level YHG=1250>of YHG=1249>IgM, YHG=1250>and YHG=1257>represents YHG=1250>possibly YHG=1260>a YHG=1259>commoner YHG=1249>form YHG=1250>of XBD=200 XHG=541 XBD=459 XBD=516 XBD=790 XBD=1003 XBD=1199 XHG=92 XHG=223 XHG=484 XHG=816 XHG=1030 YBD=1331 YBD=1323 YBD=1331 YBD=1331 YBD=1332 YHG=1294>genetic YHG=1294>predisposition YHG=1301>to YHG=1294>meningococcal YHG=1295>meningitis. YHG=1294>Certainly, XBD=159 XHG=958 XBD=189 XBD=256 XBD=337 XBD=515 XBD=573 XBD=677 XBD=865 XBD=948 XBD=982 XBD=1200 XHG=92 XHG=168 XHG=198 XHG=264 XHG=345 XHG=523 XHG=582 XHG=686 XHG=874 XHG=991 YBD=1367 YBD=1374 YBD=1376 YBD=1367 YBD=1368 YBD=1376 YHG=1339>both YHG=1338>it YHG=1338>and YHG=1338>IgM YHG=1338>deficiency YHG=1348>are YHG=1339>much YHG=1347>commoner YHG=1339>than YHG=1339>is YHG=1339>complement XBD=249 XHG=673 XBD=288 XBD=353 XBD=550 XBD=663 XBD=842 XBD=1021 XBD=1127 XBD=1200 XHG=92 XHG=257 XHG=296 XHG=361 XHG=561 XHG=850 XHG=1029 XHG=1136 YBD=1420 YBD=1410 YBD=1419 YBD=1411 YBD=1420 YBD=1420 YBD=1419 YBD=1412 YHG=1382>deficiency YHG=1383>in YHG=1391>our YHG=1383>experience. YHG=1383>While YHG=1383>properdin YHG=1383>deficiency YHG=1383>might YHG=1383>also XBD=202 XHG=847 XBD=263 XBD=490 XBD=582 XBD=725 XBD=762 XBD=835 XBD=899 XBD=1138 XBD=1198 XHG=92 XHG=214 XHG=275 XHG=503 XHG=594 XHG=739 XHG=773 XHG=911 XHG=1151 YBD=1463 YBD=1455 YBD=1463 YBD=1464 YBD=1456 YBD=1457 YBD=1456 YHG=1427>explain YHG=1426>the YHG=1427>predominant YHG=1427>male YHG=1433>pattern, YHG=1427>it YHG=1436>was YHG=1427>the YHG=1428>heat-sensitive YHG=1427>C3 XBD=264 XHG=815 XBD=339 XBD=411 XBD=495 XBD=538 XBD=600 XBD=686 XBD=804 XBD=853 XBD=1089 XBD=1132 XBD=1199 XHG=91 XHG=275 XHG=350 XHG=422 XHG=506 XHG=548 XHG=612 XHG=696 XHG=857 XHG=1100 XHG=1143 YBD=1508 YBD=1509 YBD=1508 YBD=1500 YBD=1508 YBD=1500 YBD=1501 YHG=1477>component YHG=1470>that YHG=1480>was YHG=1471>vital YHG=1478>to YHG=1471>the YHG=1471>IgM YHG=1471>killing YHG=1471>of YHG=1472>meningococci YHG=1472>in YHG=1481>our XBD=205 XHG=844 XBD=280 XBD=370 XBD=593 XBD=739 XBD=828 XBD=980 XBD=1047 XBD=1199 XHG=92 XHG=222 XHG=296 XHG=385 XHG=610 XHG=755 XHG=995 XHG=1063 YBD=1550 YBD=1544 YBD=1552 YBD=1544 YBD=1545 YHG=1516>studies, YHG=1515>and YHG=1515>IgM YHG=1515>complement YHG=1516>fixation YHG=1525>goes YHG=1516>through YHG=1515>the YHG=1516>classical

" XBD=228 XHG=91 YBD=1596 YHG=1560>pathway.

" " " " "

E. M. NETTO C. C. CUBA J. L. M. COSTA A. C. BARRETO C. ROSA P. D. MARSDEN

Leishmaniasis Laboratory, University of Brasília, Brasília, Brazil

Walderrama L, Santrich C, Saravia NG. Recurrence of tegumentary leishmaniasis. Lancet 1985; ii: 557-58. 2. Llanos-Cuentas EA, Marsden PD, Lago EL, Barreto AC, Cuba CC, Johnson WD. Human mucocutaneous leishmaniasis in Três Bracos, Bahia-Brazil. An area of Leishmania braziliensis braziliensis transmission II: Cutaneous disease: presentation and evolution Revta Soc Bras Med Trop 1984; 17: 169-77. 3. Marsden PD, Llanos-Cuentas EA, Lago EL, et al. Human mucocutaneous leishmaniasis in Três Bracos, Bahia-Brazil: An area of Leishmania braziliensis braziliensis transmission III: Mucosal disease: presentation and initial evolution. Revta Soc Bras Med Trop 1984; 17: 179-86. 4. Cuba CAC, Marsden PD, Barreto AC, Rocha R, Sampaio RN, Patzlaff L. Parasitological and immunological diagnosis of American (mucocutaneous) leishmaniasis. Bull PAHO 1981; 15: 249-59. 5. Cuba CAC, Llanos-Cuentas EA, Barreto AC, et al. Human mucocutaneous leishmaniasis in Três Bracos, Bahia, Brazil. An area of Leishmania braziliensis braziliensis transmission. I: Laboratory diagnosis. Revta Soc Bras Med Trop 1984; 17: 161-67. 6. Walton BC. Evaluation of chemotherapy of American leishmaniasis by the indirect fluorescent antibody test. Am J Trop Med Hyg 1980; 29: 747-52. 1.

Weigle KA,

XBD=1198XHG=808 XBD=156 XBD=229 XBD=313 XBD=372 XBD=484 XBD=536 XBD=612 XBD=796 XBD=841 XBD=1085 XBD=1129 XHG=119 XHG=168 XHG=242 XHG=326 XHG=385 XHG=496 XHG=549 XHG=624 XHG=853YBD=1633 XHG=1097 XHG=1142 YBD=1632 YBD=1640 YBD=1641 YBD=1633 YHG=1604>At YHG=1604>that YHG=1604>time YHG=1613>we YHG=1603>found YHG=1613>no YHG=1604>IgA YHG=1604>antibodies YHG=1611>to YHG=1604>meningococci YHG=1604>in YHG=1614>our XBD=212 XHG=851 XBD=271 XBD=328 XBD=441 XBD=612 XBD=826 XBD=903 XBD=1109 XBD=1200 XHG=92 XHG=238 XHG=295 XHG=354 XHG=466 XHG=640 XHG=929 XHG=1135 YBD=1685 YBD=1678 YBD=1683 YBD=1685 YBD=1677 YBD=1685 YBD=1677 YHG=1648>patients YHG=1657>or YHG=1648>in YHG=1649>other YHG=1649>controls, YHG=1648>supporting YHG=1648>the YHG=1648>hypothesis YHG=1648>that XBD=306 XHG=903 XBD=375 XBD=516 XBD=613 XBD=678 XBD=817 XBD=891 XBD=974 XBD=1088 XBD=1133 XBD=1197 XHG=90 XHG=319 XHG=389 XHG=529 XHG=626 XHG=692 XHG=831 XHG=987 XHG=1101 XHG=1145 YBD=1729 YBD=1730 YBD=1722 YBD=1721 YBD=1729 YBD=1721 YBD=1721 YHG=1692>meningococci YHG=1701>can YHG=1692>directly YHG=1702>cross YHG=1693>the YHG=1701>mucosa YHG=1693>and YHG=1693>gain YHG=1702>access YHG=1699>to YHG=1692>the XBD=235 XHG=966 XBD=387 XBD=457 XBD=652 XBD=762 XBD=947 XBD=995 XBD=1093 XBD=1137 XBD=1197 XHG=89 XHG=253 XHG=406 XHG=477 XHG=671 XHG=783 XHG=1008 XHG=1112 XHG=1156 YBD=1772 YBD=1766 YBD=1773 YBD=1775 YBD=1765 YBD=1765 YBD=1766 YHG=1737>meninges YHG=1736>through YHG=1737>the YHG=1737>cribriform YHG=1737>plate, YHG=1737>especially YHG=1736>if YHG=1736>there YHG=1737>is YHG=1746>no XBD=231 XHG=587 XBD=323 XBD=407 XBD=567 XBD=903 XBD=1048 XBD=1100 XBD=1199 XHG=91 XHG=251 XHG=343 XHG=427 XHG=924 XHG=1068 XHG=1120 YBD=1816 YBD=1815 YBD=1808 YBD=1814 YBD=1817 YBD=1808 YBD=1809 YHG=1786>secretory YHG=1779>IgM YHG=1779>that YHG=1779>contains YHG=1778>antimeningococcal YHG=1779>activity YHG=1786>to YHG=1786>meet

" XBD=172 XHG=89 YBD=1854 YHG=1825>them. Department of Chemical Immunology, Charing Cross and Westminster Medical School, Westminster Hospital, London SW1P 2AR

J. R. HOBBS

1 Hobbs JR, Milner RDG, Watt PJ. Gamma-M deficiency predisposing J iv: 583-86. meningococcal septicaemia. Br Med 1967; 2 Hobbs JR. IgM deficiency. Birth Defects, Orig Art Ser 1975; 11: 112-16.

to

CAPTOPRIL/METOLAZONE INDUCED RENAL FAILURE

" XBD=2425 XBD=1481RECURRENCE XBD=1596 XBD=1670 XBD=1854 XBD=1952 XBD=1994 XBD=2029 XBD=2136 XBD=2286 XBD=2318 XHG=1332 YBD=2263 XHG=1495 XHG=1609 XHG=1682 XHG=1867 XHG=1965 XHG=2009 XHG=2045 XHG=2148 XHG=2299 XHG=2329 YBD=2264 YBD=2270 YBD=2269 YBD=2271 YBD=2268 YHG=2234>SIR,-Dr YHG=2235>Wood YHG=2234>and YHG=2234>colleagues YHG=2234>(Nov YHG=2235>2, YHG=2243>p YHG=2234>1008) YHG=2234>describe YHG=2243>a, YHG=2243>reverOF SOUTH AMERICAN " XBD=2427 XBD=1373 XHG=2385 XBD=1558 XBD=1612 XBD=1820 XBD=1993 XBD=2077 XBD=2209 XBD=2366 XHG=1297 XHG=1392 XHG=1580 XHG=1635 XHG=1842 XHG=2015 XHG=2096 XHG=2230 YBD=2308 YBD=2316 YBD=2307 YBD=2315 YHG=2279>sible YHG=2279>reduction YHG=2279>in YHG=2278>glomerular YHG=2278>filtration YHG=2284>rate YHG=2278>(GFR) YHG=2278>induced YHG=2278>by LEISHMANIASIS TEGUMENTARY " XBD=2425 XBD=1449 XHG=2370 XBD=1498 XBD=1566 XBD=1745 XBD=1800 XBD=1918 XBD=1994 XBD=2042 XBD=2180 XBD=2351 XHG=1296 YBD=2351 XHG=1465 XHG=1514 XHG=1582 XHG=1762 XHG=1810 XHG=1935 XHG=2011 XHG=2059 XHG=2196 YBD=2360 YHG=2322>We YBD=2359 YBD=2352 YHG=2323>captopril YHG=2323>in YHG=2323>the YHG=2328>treatment YHG=2322>of YHG=2323>ascites YHG=2323>due YHG=2329>to YHG=2322>hepatic YHG=2322>cirrhosis. XBD=284 XHG=847 XBD=490 XBD=580 XBD=640 XBD=773 XBD=825 XBD=885 XBD=1090 XBD=1148 XBD=1201 XHG=122 XHG=305 XHG=511 XHG=602 XHG=656 XHG=796 XHG=913YBD=2393 XHG=1111 XHG=1169 YBD=2399 YBD=2394 YBD=2400 YBD=2394 YBD=2393YHG=2357>all YHG=2365>SIR,-The YHG=2364>Colombian YHG=2365>data YHG=2364>of YHG=2364>Weigle YHG=2371>et YHG=2364>stimulated YHG=2374>us YHG=2370>to " XBD=1648 XBD=1401 XBD=1430 XBD=1558 XHG=1297 XHG=1414 XHG=1443 XHG=1571 YBD=2404 YBD=2395 YBD=2396 YHG=2374>report YHG=2377>a YHG=2366>similar YHG=2376>case. |>"XBD=2426 XBD=202 XBD=268 XBD=477 XBD=529 XBD=698 XBD=932 XBD=976 XBD=1065 XBD=1199 XHG=91 XHG=213 XHG=278 XHG=488 XHG=540 XHG=710 XHG=944 XHG=987 XHG=1076 YBD=2446 YBD=2437 YBD=2438 YBD=2436 YBD=2437 YBD=2448 YHG=2409>analyse YHG=2418>our YHG=2408>information YHG=2418>on YHG=2415>recurrent YHG=2408>leishmaniasis YHG=2409>in YHG=2409>Tres YHG=2408>Brazos, " XBD=1358 XBD=1560 XBD=1693 XBD=1782 XBD=1965 XBD=2063 XBD=2191 XBD=2264 XHG=1330 XHG=1370 XHG=1571 XHG=1705 XHG=1794 XHG=1977 XHG=2075 XHG=2203 XHG=2277 YBD=2439 YBD=2449 YBD=2440 YBD=2442 YHG=2411>A YHG=2411>65-year-old YHG=2419>woman YHG=2411>with YHG=2411>rheumatic YHG=2411>heart YHG=2411>disease YHG=2421>was YHG=2411>admitted XBD=186 XHG=959 XBD=313 XBD=435 XBD=528 XBD=587 XBD=816 XBD=860 XBD=939 XBD=990 XBD=1200 XHG=90 XHG=207 XHG=334 XHG=455 XHG=550 XHG=601 XHG=835 XHG=879 XHG=1008 YBD=2488 YBD=2487 YBD=2482 YBD=2481 YBD=2481 YHG=2453>Bahia, YHG=2453>Brazil, YHG=2453>where YHG=2453>95% YHG=2453>of YHG=2452>transmission YHG=2453>is YHG=2453>due YHG=2459>to YHG=2452>Leishmania " XBD=2427 XBD=1328 XBD=1519 XBD=1653 XBD=1777 XBD=1907 XBD=1951 XBD=2067 XBD=2166 XBD=2351 XHG=1296 XHG=1343 XHG=1535 XHG=1668 XHG=1791 XHG=1923 XHG=1965 XHG=2081 XHG=2181 XHG=2365 YBD=2483 YBD=2492 YBD=2484 YHG=2455>in YHG=2456>congestive YHG=2455>cardiac YHG=2454>failure YHG=2454>(CCF). YHG=2455>A YHG=2455>mitral YHG=2455>valve YHG=2455>prosthesis YHG=2456>had " XBD=1200 XBD=257 XBD=449 XBD=568 XBD=700 XBD=819 XBD=1028 XHG=92 XHG=272 XHG=461 XHG=584 XHG=833 XHG=1042 YBD=2527 YBD=2535 YBD=2526 YBD=2526 YBD=2533 YHG=2497>braziliensis YHG=2497>braziliensis YHG=2491>(Lbb)2 YHG=2497>(table). YHG=2497>These YHG=2506>recurrences YHG=2503>represent XBD=1374XHG=716 XBD=1529 XBD=1579 XBD=1689 XBD=1766 XBD=1871 XBD=1951 XBD=2047 XBD=2108 XBD=2288 XBD=2340 XBD=2424 XHG=1295 XHG=1394 XHG=1547 XHG=1602 XHG=1710 XHG=1786 XHG=1891 XHG=1968 XHG=2067 XHG=2127 XHG=2308 XHG=2359 YBD=2527 YBD=2529 YBD=2528 YBD=2537 YHG=2500>inserted YHG=2499>in YHG=2500>1979, YHG=2499>but YHG=2499>there YHG=2499>had YHG=2500>been YHG=2509>no YHG=2500>reduction YHG=2500>in YHG=2500>pulXBD=212 XBD=292 XBD=380 XBD=501 XBD=634 XBD=770 XBD=858 XBD=1059 XBD=1198 XHG=90 XHG=224 XHG=303 XHG=393 XHG=512 XHG=647 XHG=781 XHG=870 XHG=1071 YBD=2578 YBD=2578 YBD=2570 YBD=2578 YBD=2577 YHG=2542>patients YHG=2541>who YHG=2541>have YHG=2541>shown YHG=2541>clinical YHG=2541>healing YHG=2541>with YHG=2541>subsequent YHG=2541>relapse, |>" " XBD=1425 XBD=1708 XBD=1790 XBD=1865 XBD=1948 XBD=2047 XBD=2217 XBD=2269 XBD=2425 XBD=1546 XHG=1295 XHG=1566 XHG=1729 XHG=1811 XHG=1887 XHG=1968 XHG=2068 XHG=2238 XHG=2291 XHG=1438 YBD=2580 YBD=2572 YBD=2575 YBD=2573 YBD=2581 YBD=2581 YHG=2552>monary YHG=2552>pressure YHG=2543>and YHG=2543>she YHG=2543>had YHG=2544>been YHG=2544>admitted YHG=2551>to YHG=2544>hospital YHG=2550>artery XBD=137 XHG=783 XBD=233 XBD=376 XBD=458 XBD=511 XBD=578 XBD=727 XBD=771 XBD=946 XBD=1035 XBD=1199 XHG=90 XHG=149 XHG=245 XHG=388 XHG=472 XHG=524 XHG=591 XHG=739 XHG=958 XHG=1046 YBD=2615 YBD=2622 YBD=2614 YBD=2615 YBD=2614 YBD=2622 YHG=2592>not YHG=2585>those YHG=2585>patients YHG=2585>who YHG=2586>do YHG=2592>not YHG=2586>respond YHG=2592>to YHG=2591>treatment YHG=2585>with YHG=2585>complete 25 " XBD=2424 XBD=1411 XBD=1513 XBD=1685 XBD=1861 XBD=1922 XBD=2028 XBD=2258 XBD=2324 XHG=1295 XHG=1424 XHG=1527 XHG=1697 XHG=1875 XHG=1936 XHG=2043 XHG=2272 XHG=2336 YBD=2616 YBD=2625 YBD=2624 YBD=2617 YHG=2588>several YHG=2588>times YHG=2587>requiring YHG=2594>treatment YHG=2587>for YHG=2588>CCF. YHG=2588>Captopril YHG=2597>mg YHG=2588>twice " XBD=210 YBD=2666 YHG=2629>healing. XBD=1377XHG=89 XBD=1448 XBD=1560 XBD=1602 XBD=1802 XBD=1921 XBD=1999 XBD=2180 XBD=2354 XBD=2425 XHG=1295 XHG=1387 XHG=1460 XHG=1570 XHG=1613 XHG=1818 XHG=1937 XHG=2009 XHG=2192 XHG=2364 YBD=2669 YBD=2660 YBD=2666 YBD=2667 YBD=2661 YBD=2670 YBD=2668 YBD=2662 YHG=2631>daily YHG=2641>was YHG=2632>added YHG=2632>in YHG=2631>November, YHG=2625>1984,1 YHG=2632>and YHG=2639>symptoms YHG=2632>improved YHG=2633>and XBD=152 XHG=726 XBD=215 XBD=381 XBD=427 XBD=490 XBD=632 XBD=718 XBD=843 XBD=1019 XBD=1142 XBD=1199 XHG=119 XHG=161 XHG=223 XHG=391 XHG=433 XHG=499 XHG=641 XHG=852YBD=2703 XHG=1029 XHG=1151 YBD=2711 YBD=2710 YBD=2702 YBD=2703 YBD=2703 YBD=2702 YHG=2675>In YHG=2683>our YHG=2673>follow-up YHG=2673>of YHG=2674>146 YHG=2674>patients YHG=2673>with YHG=2674>treated YHG=2680>cutaneous YHG=2674>lesions YHG=2673>for " XBD=2424 XBD=1380 XBD=1465 XBD=1530 XBD=1772 XBD=1828 XBD=1935 XBD=2110 XBD=2196 XBD=2280 XHG=1294 XHG=1404 XHG=1489 XHG=1554 XHG=1796 XHG=1852 XHG=1958 XHG=2136 XHG=2219 XHG=2304 YBD=2707 YBD=2712 YBD=2704 YBD=2705 YHG=2676>there YHG=2685>was YHG=2685>no YHG=2676>deterioration YHG=2676>in YHG=2676>renal YHG=2676>function. YHG=2675>She YHG=2686>was YHG=2676>further XBD=102 XHG=907 XBD=198 XBD=247 XBD=312 XBD=409 XBD=475 XBD=629 XBD=674 XBD=738 XBD=820 XBD=894 XBD=959 XBD=1155 XBD=1199 XHG=88 XHG=115 XHG=210 XHG=253 XHG=325 XHG=423 XHG=489 XHG=641 XHG=686 XHG=751 XHG=833 XHG=973 XHG=1167 YBD=2747 YBD=2755 YBD=2754 YBD=2746 YBD=2747 YBD=2755 YHG=2727>a YHG=2727>mean YHG=2717>of YHG=2724>two YHG=2727>years YHG=2719>7% YHG=2717>relapsed YHG=2718>in YHG=2718>the YHG=2718>skin YHG=2718>and YHG=2719>3% YHG=2718>progressed YHG=2724>to " XBD=2422 XBD=1444 XBD=1486 XBD=1614 XBD=1733 XBD=1914 XBD=2044 XBD=2171 XBD=2335 XHG=1294 XHG=1453 XHG=1496 XHG=1625 XHG=1743 XHG=1924 XHG=2054 XHG=2182 XHG=2346 YBD=2747 YBD=2749 YBD=2756 YBD=2757 YHG=2720>admitted YHG=2720>in YHG=2720>cardiac YHG=2720>failure YHG=2720>(increased YHG=2720>jugular YHG=2729>venous YHG=2729>pressure, YHG=2720>periHowever, " XBD=1199 XBD=214 XBD=370 XBD=666 XBD=721 XBD=818 XBD=969 XBD=1066 XHG=88 XHG=232 XHG=573 XHG=683 XHG=732 XHG=986 XHG=1083 YBD=2791 YBD=2791 YBD=2799 YBD=2791 YBD=2791 YHG=2762>mucosal YHG=2755>disease.2 YHG=2771>many YHG=2762>of YHG=2762>these YHG=2762>patients YHG=2771>were YHG=2762>treated XBD=1401XHG=837 XBD=1551 XBD=1810 XBD=1887 XBD=2019 XBD=2061 XBD=2090 XBD=2177 XBD=2281 XBD=2349 XBD=2422 XHG=1294 XHG=1414 XHG=1566 XHG=1826 XHG=1899 XHG=2032 XHG=2074 XHG=2104 XHG=2190 XHG=2295 XHG=2361 YBD=2798 YBD=2801 YBD=2792 YBD=2793 YHG=2764>pheral YHG=2764>oedema, YHG=2764>hepatomegaly, YHG=2765>and YHG=2764>ascites) YHG=2770>at YHG=2773>a YHG=2764>time YHG=2763>when YHG=2764>she YHG=2773>was XBD=156 XHG=748 XBD=245 XBD=508 XBD=611 XBD=699 XBD=739 XBD=940 XBD=1011 XBD=1081 XBD=1198 XHG=87 XHG=163 XHG=254 XHG=517 XHG=621 XHG=708 XHG=951 XHG=1019 XHG=1090 YBD=2835 YBD=2842 YBD=2835 YBD=2836 YBD=2834 YBD=2835 YHG=2807>with YHG=2806>weak YHG=2806>antileishmanial YHG=2806>drugs YHG=2806>such YHG=2816>as YHG=2806>nifurtimox. YHG=2806>For YHG=2806>this YHG=2815>reason " XBD=2421 XBD=1399 XBD=1590 XBD=1757 XBD=1809 XBD=1877 XBD=1978 XBD=2082 XBD=2233 XHG=1294 XHG=1412 XHG=1605 XHG=1771 XHG=1824 XHG=1889 XHG=1991 XHG=2097 XHG=2248 YBD=2843 YBD=2842 YBD=2836 YBD=2837 YBD=2844 YBD=2845 YHG=2808>taking YHG=2808>frusemide, YHG=2808>captopril YHG=2809>25 YHG=2817>mg YHG=2809>twice YHG=2807>daily, YHG=2808>digoxin, YHG=2808>thyroxine, " XBD=2423 XBD=160 XHG=846 XBD=178 XBD=263 XBD=410 XBD=554 XBD=684 XBD=770 XBD=834 XBD=926 XBD=1033 XBD=1133 XBD=1198 XBD=1471 XBD=1550 XBD=1717 XBD=1992 XBD=2069 XBD=2269 XBD=2355 XHG=88 XHG=169 XHG=192 XHG=273 XHG=422 XHG=566 XHG=694 XHG=781 XHG=937 XHG=1045 XHG=1146 XHG=1294 XHG=1488 XHG=1565 XHG=1735 XHG=2008 XHG=2085 XHG=2282 XHG=2371 YBD=2879 YBD=2877 YBD=2888 YBD=2887 YBD=2883 YBD=2879 YBD=2880 YBD=2880 YBD=2879 YBD=2886 YBD=2881 YBD=2887 YBD=2888 YHG=2850>table YHG=2857>i YHG=2850>only YHG=2850>includes YHG=2850>patients YHG=2851>treated YHG=2851>with YHG=2850>the YHG=2857>most YHG=2850>active YHG=2851>drug, YHG=2850>the YHG=2852>mianserin, YHG=2852>and YHG=2851>warfarin. YHG=2852>Spironolactone YHG=2861>was YHG=2852>introduced YHG=2852>(100 YHG=2861>mg XBD=271 XHG=476 XBD=462 XBD=671 XHG=88 XHG=284 YBD=2930 YBD=2924 YBD=2931 YHG=2894>pentavalent YHG=2894>antimonial YHG=2894>glucantime. " XBD=2423 XBD=1382 XBD=1484 XBD=1556 XBD=1616 XBD=1793 XBD=1876 XBD=1947 XBD=2120 XBD=2204 XBD=2251 XBD=2292 XBD=2361 XHG=1293 XHG=1392 XHG=1494 XHG=1564 XHG=1624 XHG=1803 XHG=1885 XHG=1956 XHG=2122 XHG=2212 XHG=2260 XHG=2305 XHG=2371 YBD=2933 YBD=2925 YBD=2924 YBD=2932 YHG=2896>twice YHG=2896>daily) YHG=2896>and YHG=2896>the YHG=2896>frusemide YHG=2896>dose YHG=2906>was YHG=2883>increased YHG=2895>from YHG=2897>80 YHG=2902>to YHG=2896>120 YHG=2905>mg XBD=270 XHG=907 XBD=348 XBD=486 XBD=572 XBD=693 XBD=831 XBD=884 XBD=972 XBD=1144 XBD=1197 XHG=117 XHG=292 XHG=370 XHG=509 XHG=594 XHG=716 XHG=853 XHG=994YBD=2967 XHG=1165 YBD=2974 YBD=2975 YBD=2968 YBD=2967 YBD=2967 YHG=2938>Although YHG=2947>our YHG=2938>relapse YHG=2945>rate YHG=2948>seems YHG=2939>similar YHG=2945>to YHG=2938>that YHG=2939>observed YHG=2939>in " XBD=2421 XBD=1382 XBD=1487 XBD=1555 XBD=1689 XBD=1833 XBD=1909 XBD=2066 XBD=2122 XBD=2209 XBD=2299 XHG=1293 XHG=1397 XHG=1503 XHG=1569 XHG=1703 XHG=1847 XHG=1922 XHG=2085 XHG=2136 XHG=2223 XHG=2312 YBD=2970 YBD=2977 YBD=2969 YBD=2968 YHG=2940>twice YHG=2940>daily. YHG=2940>No YHG=2939>further YHG=2940>diuresis YHG=2950>was YHG=2940>induced. YHG=2941>10 YHG=2940>days YHG=2939>after YHG=2940>admisXBD=240 XHG=888 XBD=301 XBD=385 XBD=602 XBD=683 XBD=742 XBD=863 XBD=957 XBD=1197 XHG=88 XHG=262 XHG=324 XHG=407 XHG=626 XHG=704 XHG=765 XHG=980 YBD=3011 YBD=3019 YBD=3012 YBD=3011 YBD=3019 YHG=2981>Colombia YHG=2991>no YHG=2982>real YHG=2983>comparison YHG=2992>can YHG=2983>be YHG=2983>made. YHG=2982>The YHG=2983>predominant " XBD=2422 XBD=1372 XBD=1435 XBD=1577 XBD=1718 XBD=1929 XBD=2043 XBD=2106 XBD=2132 XBD=2321 XHG=1294 XHG=1383 XHG=1444 XHG=1587 XHG=1727 XHG=1939 XHG=2051 XHG=2115 XHG=2140 XHG=2330 YBD=3018 YBD=3013 YBD=3021 YBD=3012 YHG=2984>sion, YHG=2984>the YHG=2984>thiazide YHG=2984>diuretic YHG=2984>metolazone, YHG=2984>which YHG=2984>has YHG=2994>a YHG=2983>synergistic YHG=2983>effect XBD=208 XHG=773 XBD=257 XBD=325 XBD=409 XBD=464 XBD=640 XBD=756 XBD=947 XBD=1093 XBD=1142 XBD=1197 XHG=87 XHG=226 XHG=274 XHG=343 XHG=427 XHG=477 XHG=657 XHG=965 XHG=1110 XHG=1160 YBD=3061 YBD=3054 YBD=3055 YBD=3056 YBD=3063 YHG=3026>parasite YHG=3026>in YHG=3026>the YHG=3035>area YHG=3026>of YHG=3026>Colombia YHG=3027>under YHG=3027>discussion YHG=3036>appears YHG=3033>to YHG=3027>be " XBD=2423 XBD=1369 XBD=1560 XBD=1637 XBD=1859 XBD=1904 XBD=2025 XBD=2168 XBD=2317 XHG=1293 XHG=1382 XHG=1574 XHG=1650 XHG=1876 XHG=1916 XHG=2038 XHG=2182 XHG=2328 YBD=3062 YBD=3055 YBD=3063 YBD=3057 YBD=3056 YBD=3065 YHG=3028>with YHG=3028>frusemide, YHG=3037>was YHG=3020>introduced YHG=3027>A YHG=3034>potent YHG=3028>diuresis YHG=3027>resulted YHG=3027>(daily .2 " XBD=108 XBD=297 XBD=500 XBD=620 XBD=693 XBD=872 XBD=923 XBD=993 XBD=1198 XHG=86 XHG=127 XHG=310 XHG=516 XHG=640 XHG=711 XHG=891 XHG=941 XHG=1011 YBD=3096 YBD=3098 YBD=3108 YBD=3100 YBD=3106 YBD=3099 YBD=3099 YHG=3069>L YHG=3070>braziliensis YHG=3071>panamensis YHG=3070>(Lbp); YHG=3071>follow-up YHG=3070>in YHG=3070>the YHG=3070>Colombian |>" XBD=1419 XBD=1543 XBD=1593 XBD=1632 XBD=1813 XBD=1887 XBD=1952 XBD=2047 XBD=2171 XBD=2236 XBD=2330 XBD=2394 XBD=2421 XHG=1293 XHG=1430 XHG=1555 XHG=1599 XHG=1718 XHG=1825 XHG=1898 XHG=1963 XHG=2057 XHG=2183 XHG=2248 XHG=2341 XHG=2403 YBD=3107 YBD=3109 YBD=3108 YBD=3100 YBD=3100 YHG=3072>urinary YHG=3078>output YHG=3071>of YHG=3073>2 YHG=3071>litres) YHG=3071>and YHG=3071>her YHG=3072>body YHG=3071>weight YHG=3071>fell YHG=3071>from YHG=3073>67 YHG=3073>7 -XBD=171 XHG=823 XBD=240 XBD=343 XBD=471 XBD=550 XBD=698 XBD=756 XBD=812 XBD=948 XBD=1020 XBD=1069 XBD=1128 XBD=1197 XHG=87 XHG=181 XHG=250 XHG=353 XHG=480 XHG=565 XHG=709 XHG=766 XHG=959 XHG=1029 XHG=1080 XHG=1138 YBD=3141 YBD=3142 YBD=3150 YBD=3143 YBD=3142 YBD=3142 YHG=3113>series YHG=3123>was YHG=3113>much YHG=3114>shorter YHG=3114>(121 YHG=3115>patients YHG=3114>for YHG=3115>six YHG=3114>months YHG=3114>and YHG=3115>44 YHG=3114>for YHG=3123>one " XBD=2236 XBD=1325 XBD=1393 XBD=1694 XBD=1725 XBD=1792 XBD=1866 XBD=2049 XBD=2109 XBD=2139 XHG=1293 XHG=1338 XHG=1496 XHG=1709 XHG=1740 XHG=1804 XHG=1879 XHG=2061 XHG=2123 XHG=2153 YBD=3144 YBD=3143 YBD=3151 YHG=3122>to YHG=3116>64 YHG=3115>Metolazone YHG=3124>mg YHG=3124>was YHG=3115>continued YHG=3115>for YHG=3116>5 YHG=3115>days. XBD=171 XHG=751 XBD=240 XBD=298 XBD=381 XBD=428 XBD=612 XBD=700 XBD=741 XBD=845 XBD=1011 XBD=1057 XBD=1141 XBD=1197 XHG=86 XHG=182 XHG=249 XHG=308 XHG=391 XHG=432 XHG=622 XHG=709 XHG=855 XHG=1019 XHG=1060 XHG=1151 YBD=3193 YBD=3185 YBD=3186 YBD=3187 YBD=3186 YHG=3157>year); YHG=3157>and YHG=3156>the YHG=3157>dose YHG=3157>of YHG=3157>antimonial YHG=3158>used YHG=3158>in YHG=3158>about YHG=3157>one-third YHG=3157>of YHG=3158>what YHG=3167>we " XBD=2421 XBD=1416 XBD=1490 XBD=1645 XBD=1713 XBD=1811 XBD=1864 XBD=1955 XBD=2047 XBD=2156 XBD=2311 XHG=1328 XHG=1429 XHG=1505 XHG=1661 XHG=1727 XHG=1826 XHG=1872 XHG=1967 XHG=2061 XHG=2169 XHG=2329 YBD=3193 YBD=3195 YBD=3186 YBD=3188 YBD=3187 YHG=3159>After YHG=3159>this YHG=3159>diuresis, YHG=3158>the YHG=3159>signs YHG=3158>of YHG=3158>CCF YHG=3168>were YHG=3158>much YHG=3158>reduced. YHG=3158>HowUnlike " XBD=1197 XBD=229 XBD=480 XBD=529 XBD=626 XBD=783 XBD=992 XHG=87 XHG=245 XHG=497 XHG=548 XHG=644 XHG=1011 YBD=3238 YBD=3229 YBD=3230 YBD=3231 YBD=3231 YHG=3200>normally YHG=3202>recommended YHG=3201>in YHG=3202>Tres YHG=3195>Bracos.3 YHG=3201>the YHG=3199>Colombian XBD=1373XHG=940 XBD=1450 XBD=1591 XBD=1811 XBD=1873 XBD=2013 XBD=2191 XBD=2278 XBD=2421 XHG=1293 XHG=1398 XHG=1474 XHG=1615 XHG=1834 XHG=1890 XHG=2038 XHG=2216 XHG=2299 YBD=3239 YBD=3230 YBD=3236 YBD=3237 YBD=3238 YHG=3212>ever, YHG=3202>the YHG=3202>patient YHG=3202>complained YHG=3202>of YHG=3211>nausea, YHG=3202>anorexia, YHG=3203>and YHG=3202>general XBD=256 XHG=767 XBD=315 XBD=410 XBD=499 XBD=581 XBD=629 XBD=750 XBD=913 XBD=1011 XBD=1197 XHG=87 XHG=271 XHG=331 XHG=426 XHG=514 XHG=597 XHG=645 XHG=930 XHG=1026 YBD=3280 YBD=3282 YBD=3273 YBD=3274 YBD=3281 YBD=3274 YHG=3244>experience YHG=3254>we YHG=3254>were YHG=3245>only YHG=3245>able YHG=3252>to YHG=3245>isolate YHG=3246>parasites YHG=3246>from YHG=3246>individual " XBD=2421 XBD=1426 XBD=1518 XBD=1588 XBD=1767 XBD=1807 XBD=1901 XBD=2020 XBD=2152 XBD=2237 XBD=2263 XHG=1293 XHG=1439 XHG=1527 XHG=1598 XHG=1776 XHG=1818 XHG=1910 XHG=2028 XHG=2161 XHG=2247 XHG=2273 YBD=3283 YBD=3274 YBD=3275 YHG=3246>malaise. YHG=3246>This YHG=3255>was YHG=3245>attributed YHG=3253>to YHG=3246>renal YHG=3246>failure YHG=3245>(figure) YHG=3245>with YHG=3255>a YHG=3246>resultant " XBD=2422 XBD=1428 XBD=1485 XBD=1627 XBD=1786 XBD=1999 XBD=2162 XBD=2338 XHG=1293 XHG=1453 XHG=1509 XHG=1650 XHG=1812 XHG=2022 XHG=2185 XHG=2362 YBD=3324 YBD=3318 YBD=3325 YBD=3317 YHG=3290>increase YHG=3289>in YHG=3289>plasma YHG=3289>digoxin. YHG=3289>Interaction YHG=3290>between YHG=3289>captopril YHG=3290>and XBD=164 XHG=790 XBD=212 XBD=380 XBD=452 XBD=599 XBD=727 XBD=779 XBD=925 XBD=1127 XBD=1199 XHG=87 XHG=176 XHG=217 XHG=392 XHG=462 XHG=611 XHG=738 XHG=937 XHG=1138 YBD=3317 YBD=3316 YBD=3325 YBD=3326 YBD=3318 YBD=3318 YHG=3296>cases YHG=3288>of YHG=3295>cutaneous YHG=3290>and YHG=3289>mucosal YHG=3289>relapse YHG=3290>by YHG=3289>hamster YHG=3290>inoculation " XBD=275 XBD=373 XBD=415 XHG=87 XHG=288 XHG=384 YBD=3361 YBD=3360 YBD=3361 YHG=3331>characterise YHG=3332>them YHG=3342>as YHG=3333>Lbb. " XBD=506 XBD=1484XHG=428 XBD=1556 XBD=1740 XBD=1814 XBD=1901 XBD=2005 XBD=2095 XBD=2334 XBD=2422 XHG=1293 XHG=1494 XHG=1567 XHG=1753 XHG=1824 XHG=1911 XHG=2015 XHG=2106 XHG=2346 YBD=3368 YBD=3360 YBD=3366 YBD=3361 YHG=3332>metolazone YHG=3342>was YHG=3332>suspected, YHG=3332>and YHG=3331>both YHG=3332>drugs YHG=3341>were YHG=3332>discontinued, YHG=3332>with " XBD=2420 XBD=1308 XBD=1512 XBD=1633 XBD=1679 XBD=1812 XBD=1911 XBD=2078 XBD=2218 XBD=2283 XHG=1292 XHG=1323 XHG=1527 XHG=1647 XHG=1693 XHG=1827 XHG=1925 XHG=2095 XHG=2231 XHG=2297 YBD=3405 YBD=3412 YBD=3411 YBD=3403 YBD=3404 YHG=3386>a YHG=3377>subsequent YHG=3382>return YHG=3382>to YHG=3376>normal YHG=3375>renal YHG=3375>function. YHG=3375>During YHG=3375>the YHG=3376>metolaXBD=184 XHG=868 XBD=321 XBD=518 XBD=680 XBD=783 XBD=855 XBD=944 XBD=1023 XBD=1198 XHG=118 XHG=196 XHG=334 XHG=532 XHG=691 XHG=796 XHG=957YBD=3404 XHG=1035 YBD=3402 YBD=3403 YBD=3412 YBD=3405 YBD=3412 YHG=3375>The YHG=3375>indirect YHG=3375>fluorescent YHG=3376>antibody YHG=3376>(IFA) YHG=3383>test YHG=3376>with YHG=3376>IgG YHG=3376>conjugate XBD=143 XHG=887 XBD=214 XBD=423 XBD=583 XBD=644 XBD=782 XBD=852 XBD=940 XBD=1130 XBD=1204 XHG=87 XHG=177 XHG=248 XHG=459 XHG=620 XHG=680 XHG=819 XHG=975 XHG=1166 YBD=3446 YBD=3455 YBD=3447 YBD=3448 YBD=3455 YHG=3418>and YHG=3427>an YHG=3419>amastigote YHG=3420>antigen YHG=3419>is YHG=3419>useful YHG=3420>in YHG=3419>the YHG=3420>diagnosis YHG=3419>of " XBD=2422 XBD=1369 XBD=1628 XBD=1690 XBD=1846 XBD=1952 XBD=2104 XBD=2175 XBD=2289 XHG=1292 XHG=1380 XHG=1639 XHG=1701 XHG=1856 XHG=1961 XHG=2114 XHG=2184 XHG=2298 YBD=3455 YBD=3456 YBD=3447 YBD=3448 YHG=3428>zone YHG=3419>administration YHG=3418>the YHG=3419>patient’s YHG=3419>blood YHG=3428>pressure YHG=3419>and YHG=3428>serum YHG=3419>sodium " XBD=1553 XBD=1345 XBD=1419 XHG=1292 XHG=1356 XHG=1432 YBD=3491 YBD=3499 YHG=3463>fell YHG=3464>(see YHG=3462>figure). XBD=336 XHG=895 XBD=606 XBD=674 XBD=722 XBD=820 XBD=861 XBD=886 XBD=953 XBD=1076 XBD=1138 XBD=1197 XHG=87 XHG=347 XHG=618 XHG=684 XHG=731 XHG=830 XHG=870 XHG=963YBD=3491 XHG=1086 XHG=1147 YBD=3493 YBD=3492 YBD=3492 YBD=3492 YBD=3500 YHG=3469>mucocutaneous YHG=3456>leishmaniasis YHG=3464>but YHG=3463>its YHG=3463>value YHG=3473>as YHG=3473>a YHG=3470>test YHG=3463>of YHG=3464>hascure YHG=3469>yet 4,5 ,

5-3 3kg.

7