Immunology (3rd edn)

Immunology (3rd edn)

kaleidoscope letters Utsuyama, M. and Hirokawa, K. (1988) Autoimmumta' 5, 215-228 5 Murphy,E.D. andRoths, J.B. ( I 9v8) in Genetic Contr,;i of Autoimm...

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kaleidoscope letters Utsuyama, M. and Hirokawa, K. (1988) Autoimmumta' 5, 215-228 5 Murphy,E.D. andRoths, J.B. ( I 9v8) in Genetic Contr,;i of Autoimmune Disease (Rose, N.R., Bigazzi, P.E. and Warner. N.L., eds), pp. 207-221, Elsevier 6 Avrameas, ~. (1993)in N,ltural Aut. ,,ln:ihodies - Their Physiologic,ll

t,S, 1412-1415 2 Ansac Ahmed, S., Dauphinee, .M.J., .Momova, A.I. and Talal, N. (1989~ I. hnmun, d. 142, 264--2653 3 Ansar Ahmed, S. and Verthelyi, D. ~1q93) .]. Altt,inimtot. ~,. 26~-2-0 4 Ha vashi, "t,, Deguchi, H., Nakahata, A., Kurashima, C.,

Role and Regulatory Significance (Shoenfeld, Y. and lsenberg, D.A., eds), pp. 1-14, CRC Press 7 Gordon, G.B., Shantz, LM. and Talala~; E (1987)Adz: Enzymol. Regul. 26, 355-382 8 Ansar Ahmed, S., Penhale, W.J. and Talai, N. (1985) Am. J. Patbol. 121, 531-551

chromosome-walking studies -~showed evolved independently in the rat and that there are several clusters of in the mouse. duplicated TEa-like genes, and one Thomas J. Gill, III such gene was isolated from a cDNA library and sequenced (RT1.N3, which is 92.8% similar to RTI.N1 ). Dept of Patholog3; The article bv Kronenberg et al. University of Pittsburgh School of Recently, a Q-like pseud%ene, is an interesting review of the evolMedicine, ution of the major histocompati- RI-1.0, that lacks exons a2 and a3, Pittsburgh, bilitv complex (.MHCk but it mis- has been isolated and sequenced PA 15261, states a point that is quite important from the same library as the USA. in considerations of this issue: TLa- TLa-like genes, and it has been like and Q-like genes have both been mapped relative to RT1.G (Ref. 4). The nucleotide sequence of this References described in the rat. 1 Kronenberg, M., Brines, R. and The TLa-like gene was first des- gene shows approximately 85% ignated RT(5.8)(Ref. 2) and later similarity to the mouse Q and Kaufman, J. (1994)hnmunol. Today renamed RTI.NI. It is expressed H-2 genes, 32% similarity to the 15, 4-6 only in the thymus, and has a mouse T10 b gene, 46% similarity 2 Kirisits,M.J., Kunz, H.W., nucleotide sequence that is consider- to the rat RTI.N genes and 80% Cortese Hassett, A.L. and Gill, T.J., III (1992) hnmunogenetics 35,365-377 ably more similar to some mouse similarity to the rat RT1.A and Pa 3 Kirisits, M.J., Sawai, H., Kunz, H.W. T genes {60--65%) than to mouse Q genes. and Gill, T.J., III (1994) 143%) or H-2D (51%) genes, or to The existence of TLa-like and Q- bnmunogenetics 39, 301-315 rat RTI.A or Pa (42-51%) genes. like genes in the rat supports the 4 Rushton, J.J., Misra, D.N., Subsequentb; this gene was found to hypothesis that the three major Kunz, H.W., Cortese Hassett, A.L. and be duplicated to form the RTI.N2 groups of class I genes (RT1 .ME, H- Gill, T.J., 1II Eur. J. hnmunogenet.

MHC evolution: a long-term investment in defense





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book reviews The first edition of h'an Roitt's classic teaching text Essential Immunology appeared almost two decades ago. As the field has changed and become more complex, can basic textbooks still provide as smooth an entry into the world of the immune system? Here, we review three candidates for the coveted 'standard text' mantle.

Immunology (3rd edn) edited by h'an Roitt, Jonathan Brostoff and David Male, Times Mirror International Publishers, 199,3. £19.95 cxii + 363 pages) ISBN 0 397 -~476S S In the preface to the original edition of hnnlunology, the editors wrote: "we believe this to be a remarkably unusual book". Eight years later, and four years on from the first revision, this is certainly

true of the latest edition. With emphasis on presentation as much as scientific content, this book succeeds through the combined efforts of immunologists, editors, publishers and graphic artists. The third edition of hnmunology is a visually striking volume. The book retains many overall outlines of familiar multicoloured diagrams from previous editions, all skilfully redrawn to great effect. The figures are now in lucid (and sometimes lurid) new colours and, together

hnmunoh,g3, Today

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with other clever alterations to the layout, this helps grab the attention and makes for a fascinating read. I especially qke the ingenious combination of colt, ur photographs of histology sections and miniature explanatory line drawings - a device that worked well in previous editions and is retained for this latest revision. Many photographs in the third edition are improved in print quality, although the eosinophil that made its initial appearance on page

Vol. 15 No. 8 1994

kaleidoscope book reviews 2.13 of the first edition is still out of focus in the third! More importantly, the text is much revised: extended here and there, trimmed elsewhere, and as up-to-date as one could hope for in a book of such ambitious scope and scale. Several new authors have joined the line-up, and a fresh perspective is no bad thing in an authoritative textbook. There are valuable new chapters on 'Antigen Receptor Molecules', 'lmmunodeficiency' and 'Cell Migration and Inflammation'. The 'Tumour Immunology' chapter has regressed in size, a few pages on major human parasites have been eradicated, and suppressor cells have been stifled. The addition of a short appendix

deals with major histocompatibility complex (MHC) HLA specificities, CD markers and properties of the major cytokines. All in all, this is ,', splendid revision with only a few minor drawbacks. For instance, some of the chapters on new subjects are skimpy, although this may be a consequence of the speed of progress in specific fields during the production time of the book. And, in the chapter on 'Immunological Techniques', some details of molecular biological methods with relevance to immunology (such as polymerase chain reaction and Southern blotting) might have been useful. This latest edition of bnmunology is a pleasure to see and to read

end, while some of the changes nay sound cosm~,fic, thev are also enterprising and substantial. Immunology should be essential reading for all undergraduate students of the subject. It will be a valuable book for many others with an interest in immunoloD; whatever stage they are at. At a time of serious erosion of student grant support in the UK, this book has the additional advantage of remaining affordable.

pletely divorced from the clinic. The closest rival to the present text, the similarly titled Celhdar and Molecular bnmunology by A.K. by J.M. Austyn and K.J. Wood, Abbas, A.H. Lichtman and J.S. Oxford University Press, 1993. Pober (W.B. Saunders), does at least £25.00/$42.50 (xi + 746 pages) ISBN make some attempt to fit the nuts 0 19 854195 3 and bolts of immunology into the context of human disease. A potentially bewildering array of However, little of the wealth of immunology textbooks now con- information in the book by Austyn fronts the stude.:)t who ventures into and Wood is other than superficially their nearest medical or science put into such a context. The primary appeal of this book book shop. One must therefore question the need, and indeed the will be to those who seek a greater motive, for any addition to the depth of coverage than that found in already groaning shelves of im- most immunology texts (28 pages munology texts. Nonetheless, whilst on idiotypes, 15 pages on dendritic Principles of Cellular and Molecular cells, and so forth). This depth is Immunology is perhaps not quite matched by an authoritative writing 'the ultimate immunology textbook' style and, for a textbook, fairly that the publishers would have us extensive referencing. Parts of the believe, it does possess several fea- text, discussing experimental findtures that, taken together, overcome ings or adding extra detail, are shaded in grey so that they may be any initial reservations. The authors' ~t~'_..,,.,~'aim ~s to pro- skipped by the relatively less invide a comr~ ehensive introduction quisitive. The artwork may lack the to celluLr ,:,d ..,,,',ocular immu- visual appeal found in some other nology fci undergraduate science immunology textbooks, but manstudem,, postgraduate research ages well enough to convey its messstudents and clinicians. This is a age in a clear and concise fashion. Each chapter is preceded by a fullbr,,ad constituency and the book :could seem poorly matciled to the page diagram, of a standard format, major requirements of many of the in which the topic to be covered in latter group. Indeed, therein lies that chapter is mapped out. This 'he rub, for the content adheres idea is of varying success depending absolutely to the title. Although this on the particular chapter in quesis quite fair, the result is that tion, but would prove useful in the immunology becomes almost corn- form of an overhead as a launch pad

for tutorials covering that chapter. For those unfamiliar with particular experimental protocols, an appendix is provided illustrating some of the techniques referred to in the text. However, it is the introductory chapter that is, quite literally, a revelation. Here, we are treated not simply to the usual overview of immune responses, but are provided additionally with all the basic non-immunological background that is so esser, aal for a .-,..,,. . . . . nA,~.~.a..A;~g ~g.;. . . . . . I.... [~lX.l[J' U l t A d t c , . . i a t ii~Iiii Ul IllilllUllVJrlU~ff itself. Thus, you will find key information about amino acids, oligosaccharides, nucleic acids, genes, cell structure, cell cycle, and so forth. This is a splendid idea as it does not take up a great deal of space and yet saves the student the need to have, for instance, a biochemistry book next to them whilst try,ng to grasp the finer points of the interactions between the major histocompatibility complex (MHC) and peptide. A book that so blatantly ignores the patient has little claim on the title 'the ultimate immunology textbook'. However, for tile student requiring an in-depth coverage of the areas circumscribed by the title, this is an excellent text.

Principles of Cellular and Molecular Immunology

Immunology Today


Keith Guy

Dept of lmmunoh~g3, University of Strathch.,de, Glasgow, UK G40NR.

Vol 15 No. 8 1994

Peter J. Delves Dept of Immunology, University College London Medical School, 40-50 Tottenham Street, London, UK W1P 9PG.