there is no evidence that people with facial paralyses lack emotion. This is an example of ways in which observation of people with neuromuscular disorders can influence thinking on wider topics. Laughing may or may not provide an "oxygen bath for the brain" but many parts of the book are entertaining as well as instructive. The diversity of topics--from what characterizes a top ball player to a Garfield cartoon, from rats in mazes to neonates mimicking maternal facial expression--makes the book suitable for students with a wide general interest. It is intended as an introductory text for students of behavioural science. However, it quotes about a thousand authors and includes an informed account of such aspects of research as computer modelling. Readers of Neuromuscular Disorders will look in vain for substantial biological insights--more black boxes and arrows than electron microscopy and action potential. They will find the book informative about movement, however-" W h y " rather than " H o w " .
reference source to direct the reader to specific clinical examinations and procedures. There are a few complaints regarding the sequencing of the text. Although the individual sections are well written with clear line drawings, I did not find that the order within each section followed a natural progression. A comprehensive assessment and treatment plan by region would have been preferable. In addition, readers with little experience of manual techniques, would be recommended to initially read the final chapter, entitled "therapy". This book should be a source of stimulation for physicians not only to approach differently the assessment and treatment of many clinical complaints but to undertake further research and reading.
J. N. A. GmSON Department of Orthopaedic Surgery University of Edinburgh
Neurotransmitter Release: The Neuromuscular Junction. Edited by F. CLEMENTI and J.
IAN MCKINLAY Department of Child Health University of Manchester
Manual Medicine. JIR! DVORAK and VACLAV
DVORAK. Published 1991 by Georg Thieme, Stuttgart. ISBN 3 13 757701 2, 185 pp. Price DM25. There is an increasing awareness amongst physicians and other health care workers of the beneficial effects of manual therapeutic techniques, yet a lack of basic knowledge as to how these should be undertaken. This small reference guide to diagnosis and treatment is therefore to be welcomed. I would expect it to be of particular value to rheumatologists and orthopaedic surgeons with an interest in spinal disorders. Based on their two manual medicine reference books, the authors Dvorak have produced an integrated text in which they detail the clinical and radiological examinations which are relevant to the practice of manipulative therapy. Elementary biomechanical and anatomical considerations are also discussed. This book is certainly not designed for reading from cover to cover. It will find its rightful place in a coat pocket or on a clinic bookshelf, from where it may be produced, and used as a
MELDOLESI. Published 1990 by Academic Press, London. ISBN 0 12 176460 5, 232 pp. Price £19.50. This authoritative monograph on neurotransmitter release at the neuromuscular junction contains the contributions presented at a memorial symposium held in 1989 for Bruno Ceccarelli, the Italian neurobiologist who had died in 1988 at the early age of 50, and whose own distinguished research had been focused on the neuromuscular junction. The monograph contains many state-of-theart papers, de Camilli's group review secretory organelles of neurons, specifically small synaptic vesicles and large dense core vesicles, arguing that the neuronal pathways they serve are distinct, conferring on the nervous system the property on the one hand of propagating information at high speed and, on the other, of undergoing longer-lasting plastic changes. The functional, molecular and biological aspects of the synaptic vesicle membrane and its recycling are described in a full paper by Zimmermann and colleagues, and Heuser discusses the role of coated vesicles in recycling of the synaptic vesicle membrane. Synapsins are dealt with in two papers by Greengard and colleagues. Molenaar reviews his studies with Polak and