No cloning, no shelf-life

No cloning, no shelf-life

TiPS - February 90 heparin analogues, many of which clinical undergoing are IIOIV evaluation. The editors end the preface to this book by saying that...

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TiPS - February

90 heparin analogues, many of which clinical undergoing are IIOIV evaluation. The editors end the preface to this book by saying that they ‘IKJ~UT this book zvill fill n perceive&

nic!te ntld be of use to researchers, techrticinns, clinicians, and workers i,t ijldustry’. My opinion is that their hope has been fulfilled and that there is something in this book for everybody. It deserves to

become heparin.

No cloning, no shelf-life

disease states. These chapters are balanced and well written. Overall, the volume is a useful addition to the texts available to students of neuropharmacology. It offers a fairly up-to-date review, at reasonable cost. A shortcoming of the book, however, is its failure to make any mention of the ‘new biology’ and its already major impact on this area of research. The molecular biology of receptors, revealing hitherto unsusfamily relationships pected among receptors and a wealth of is rapidly multiple subtypes,

providing information on the detailed mulecular architecture of receptor proteins. This omission will inevitably give the volume a ‘dated’ look within a very few years, and a second edition will soon be needed to take account of these new and startling advances. Meanwhile, this volume serves its purpose well.

New editions

with a final section of selfcontained chapters offering more detailed information on selected aspects of clinical pharmacokinetics.

Neurotransmitters, Disease



edited by R. A. Webster and C. C. Blackzuell Sciezatific Publications. 1989. E29.50 (474 pqed lSBN 0 632 00727 6


Despite the rapid growth of research interest in studies of neurotransmitters and neuropeptides there are few texts suitable for undergraduate or postgraduate students. This volume aims to fill this niche, in which it competes with the still admirable lrzfroduction to Biochemical Neuropharmcolo~~ by Cooper, Bloom and Roth (Oxford Press). The 22 chapters are all by British authors, demonstrating the continuing scientific appeal and strength which neuropharmacology holds in the UK. The first five chapters review basic aspects of synaptic transmission and describe how synaptic pharmacology can be studied by neuroanatomical, electrophysiological, radioligand binding and other biochemical methods. A further ten chapters review in more detail the individual neurotransmitter monoamines, amino acids and neuropeptides, with emphasis on their interactions W;th postsynaptic receptors and the pharmacology of drugs that act on these receptors. A novel and attractive idea was to end the book with a series of seven chapters devoted to ‘applied neuropharmacology’, each dealing :vith what is known about the neurotransmitter imbalances and drug treatments for particular clinical conditions. These include Parkinson’s disease and other movement disorders, the epilepsies, schizophrenia, depression, anxiety, Alzheimer’s disease and pain. This section will appeal to clinical readers and to those who are interested in applying basic knowledge of neurotransmitter mechanisms to human

Drugs Handbook 1989-1990 by Paul Turner and Glyn Volans, Macmillun, 1989. Ea.95 (xv + 183 pages) ISBN 0 333 46753 1 This useful book lists mechanisms, indications and chief sideeffects of drugs under their generic names. A second section gives crossreferences between trade names and generic names. Designed to help all those involv4 in health care, particularly in the UK, this new edition includes drugs introduced up to June 1989. Clinical Pharmacokinetics: Concepts and Applications. Second edition by Malcolm Rowland and Thomas N. Tozer, Lea 6 Febiger, 1989. E28.23 (x + 541 pages)ISBNO812111605 In revising this book the authors have taken account of important recent advances in the field of clinical pharmacokinetics, notably the finding that pharmacokinetics is the major cause of variations in drug responses. The book has also been reorganized into four sections covering absorption and disposition kinetics, therapeutic regimens, physiological concepts and kinetics, and factors accounting for variability of response,


1990 [Vol. 211


text CLIVE


of Plmrnncology, Kings Coiicge Lorrdorr, Mawesn Rand, Lorldorl SW3 6LX,





Merck Sharp t3 Dohme Research Laboratories, Neuroscieme Resenrch Centre, Terlings Park, Enstwick



Essex CM20 2QR,


Guidelines on the Care of Laboratory Animals and their Use for Scientific Purposes II: Pain, Analgesia and Anaesthesia Universities Federation Welfare, 2989. E2.50 ISBN 0 900767 61 8

for Animal 126 pages)

This short guide is intended to help those involved in the care of laboratory animals to meet their obligations under the UK Animals (Scientific Procedures) Act, 1986. It is available from UFAW, 8 Hamilton Close, Soukh Mimms, Potters Bar EN6 3QD, UK. Lecture Notes on Clinical Pharmacology. Third edition by john I;. Reid, Peter C. Brian Whiting, Blackwell Publications, 2989. E22.95 pages) ZSBN 0 632 02573

Rubin and Scientific (ix + 271 5

In the third edition of this student text, several chapters have been rewritten and a new chapter on thrombolytic therapy has been added. The book aims to emph,asize principles, and highlight rapidly developing and important areas, rather than provide comprehensive coverage.