perfused under anesthesia, and the choroid plexus was removed from the lateral ventricles of the brain. The specimens were then processed for routine scanning electron microscopy and examined using JSM-850 scanning electron microscope. Results. There was a rapid secretion of cerebrospinal fluid at five days following 5,7-DHT or 6-OHDA administration, and recovery to normal blebbing cycle occurred at about 20–30 days following selective denervation. Conclusions. These findings indicate that serotonergic and sympathetic innervations have inhibitory action on cerebrospinal fluid production. The recovery to normal blebbing cycle could be either due to the regeneration of sertonergic and adrenergic fibers in the ventricular lumen or due to some other compensatory mechanisms that restore the normal functioning of the choroid plexus. Thus, this study clearly demonstrates the impact of these and related selective neurotoxins in neuroscience research. doi:10.1016/j.yebeh.2012.04.100
Correlative variables in brain mapping and digital EEG in patients with severe craneoencephalic trauma in early states T. Montes de Oca D, J.M. Rojas de Dios, I. Padrón López, G. Maya Morales, O. González Pérez, Department of Clinic Neurophysiology, General University Hospital Camilo Cienfuegos, Sancti Spiritus, Cuba The craneoencefalic traumas are the third leading cause of death in our country; motor vehicle accidents remain the leading cause of admission to the health units. Major complications in the first few months are the bruises and post-traumatic epilepsy. Objective. The aim of this study was to evaluate quantitative EEG brain mapping in the first two weeks of trauma, with the aim of locating statisticians' predictive variables of these complications and to establish an effective treatment for patients in the initial stage. Methods. We scanned 52 patients admitted to the Intensive Care Unit, 34 men and 18 women, with ages 18 to 65 years, with montage 10–20 in MEDICID 4. Results. The analysis by quantitative methods CROSS and BCROSS indicated the presence of delta activity in the focal polymorphic frontoparietal regions in 39 patients; with areas of low density and frequency of signs of moderate cortical dysfunction being operated on 34 patients with the presence of haematoma located at these levels, 11 patients showed paroxysmal activity in the focal centre-parietal region, well defined in the analysis of maps frequently by Mahalanobis, of whom 10 patients had partial seizures in the third week of trauma. In the study of evolution at the two and six months under treatment, we note only in 3 patients with delta activity and the persistence of paroxysmal activity in 15 patients, the intensity of cortical dysfunction was very light. Conclusions. The EEG quantitative brain mapping is very important to establish a rapid and effective medical treatment in the first two weeks of severe cranial trauma and to prevent late complications such as epilepsy.
Partial agenesis of corpus callosum in Sanjad–Sakati syndrome (p-ACC) N. ALGhasaba, B. Janatib, A. Khanc, aQassim University, Saudi Arabia, b Center for Neurology, Fairfax, VA, USA, cKing Khaled Hospital, Hail, Saudi Arabia
Introduction. Sanjad–Sakati syndrome (SSS) was first described in the Middle East in children of consanguineous parents . It is a rare autosomal recessive disorder known also as Middle-East syndrome. Methods. The Clinical investigation was conducted at King Khaled Hospital in Hail, Saudi Arabia in 2011. Results. General physical examination showed the patient to be shortstatured with facial dysmorphic features including a long narrow face, deep-set eyes, peaked nose, depressed nasal bridge, micrognathia, thin lips, low-set and large floppy ears, small hands and small feet. The brain MRI in our patient showed a partial agenesis of the corpus callosum (p-ACC) characterized by the absence of the splenium and rostrum of this structure. Conclusion. Our patient showed partial agenesis of the corpus callosum which could explain the patient's motor, behavioral and developmental abnormalities (reference). The wide variety of MRI presentations reported in the SSS literature may represent different gene mutations. MRI image was taken and will be involved to the poster after acceptance.
Changes of amygdalae in systemic lupus patients with epilepsy K. Peterováa, J. Brabecb, R. Svobodovác, M. Fojtíkovác, Z. Potyšovád, A. Vojtěchováa, V. Peterováa, P. Petrovickýb, aMR Dept., Radiodiagnostic Clinic, Czech Republic, bInstitute of Anatomy, Czech Republic, cInstitute of Rheumatology, Czech Republic, dDept. of Nephrology, First Faculty of Medicine, Charles University in Prague, Czech Republic Objective. This study aims to analyze slight changes of the amygdalae and their volumetry in patients with systemic lupus erythematosus (SLE) with neuropsychiatric symptomatology (NPSLE), because patients with depression and mood disorders had been reported to have disability of the amygdalae, changes in size and activity, which in some studies correlated with the severity of depressive episodes. NP-SLE includes cognitive deficits to dementia, mood disorders, depression, stroke, epilepsy, etc. We performed amygdalar volumetry by semiautomatic method in special software, using their manual contoured rims in sequence using thin slices. Methods. We investigated 23 female patients with proved NP-SLE, aged 19 to 67 years, who were recruited for a prospective longitudinal neuroimaging study conducted using a 1.5-T MR device. Findings were statistically processed and compared with corresponding healthy persons. Results. In our study we found that in patients with active NP-SLE, the right amygdala correlated, with respect to all monitored parameters, with only the left amygdala (p = 0.01) and the left amygdala correlated with the right amygdala (p = 0.01) with volumetry in flow atenuation inversion recovery (FLAIR) and T1-weighted images (p = 0.05). Conclusions. We failed to demonstrate significant volume change in the amygdalae in the sample of NP-SLE patients. We did not demonstrate significant difference of amygdalar volume due to the duration of NP-SLE or age of the patients. The authors' research was supported by the research project MZO 0006416 and 000 000 23728.