Peer review report 1 on “Primary thyroid lymphoma: A case report and review of the literature”

Peer review report 1 on “Primary thyroid lymphoma: A case report and review of the literature”

Annals of Medicine and Surgery 13 Supplement 1 (2017) S63 Contents lists available at ScienceDirect Annals of Medicine and Surgery journal homepage:...

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Annals of Medicine and Surgery 13 Supplement 1 (2017) S63

Contents lists available at ScienceDirect

Annals of Medicine and Surgery journal homepage: www.annalsjournal.com

Peer Review Report

Peer review report 1 on “Primary thyroid lymphoma: A case report and review of the literature” 1. Original Submission 1.1. Recommendation Minor Revision 1.2. Comments to the author I think this is an important case which illustrates a rare primary thyroid lymphoma well. Including both macroscopic and microscopic pictures are useful. I feel the Introduction should focus more on how this case adds to the literature. The discussion gives a good overview of primary thyroid lymphoma. However, it would be useful to link it back to the case presented in in this paper in order to illustrate the significance of the case and put the discussion in context. Fine need aspirate was used as a procedure on this patient. It would be worth discussing in more detail the limitations and the effect of the differential diagnoses. Introduction: I think the Introduction is best for presenting the importance of the case. It would be worth explaining the importance of this case report in context of the current literature and its rarity in clinical practice. “Surgery is not the first line therapy for this entity and should be reserved for selected cases.” I think this sentence may be better placed towards the end of the paper. Page 9 paragraph commencing with “PTL is more prevalent in female patients” - I think it would be useful to reference some of this back to the case to put it into context Page 9 “its role in the diagnosis of PTL is of limited value”- It

DOI of published article: http://dx.doi.org/10.1016/j.amsu.2016.12.023. http://dx.doi.org/10.1016/j.amsu.2017.01.002 2049-0801

would be worthwhile detailing why PTL is of limited value -eg nonspecific histological findings etc. You have mentioned that it is difficult to discriminate between the differential diagnoses but should discuss what leads to these difficulties and the significance of one diagnosis over the other (for example would one diagnosis have a worse prognosis than the other?) Further down you have mentioned “Demharter et al13 recently demonstrated that corebiopsy diagnoses and classifies 95% of lymphomas, but there is no definitive data regarding specifically the PTL. This technique may be helpful in patients in whom FNAC was not diagnostic but the suspicion is high.” This may be more pertinent when discussing the limitations of FNAC in another section. Please note grammatical errors- on page 8: Two years after de diagnosis the patient is free of disease. On page 9: there is no definitive data regarding specifically the PTL Page 10 “Given that MALT lymphomas do not represent the most part of PTL, surgery is not the primary treatment” - Does the daughter's diagnosis of MALT lymphoma change the differentials in this patient? Karishma Shah, Academic Foundation Doctor Oxford University Clinical Academic Graduate School, Oxford University Hospitals, Room 3600, Medical Sciences Divisional Office, Level 3, John Radlciffe Hospital, Oxford, United Kingdom E-mail address: [email protected]