SERUM LACTIC DEHYDROGENASE ISOENZYMES IN MYXEDEMA HEART DISEASE

SERUM LACTIC DEHYDROGENASE ISOENZYMES IN MYXEDEMA HEART DISEASE

DOLARA, 4 DEMUTH, “Myocardial 434, 1965. 5 W., JR. AND contusion,” R. KISSANE, Circulation, 6 L. SIGLER, Incidence of severe 1.. 30:459, 7 WATSO...

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DOLARA, 4 DEMUTH, “Myocardial 434, 1965. 5

W., JR. AND contusion,” R.

KISSANE,

Circulation, 6

L.

SIGLER,

Incidence of severe 1.. 30:459, 7 WATSON, “Cardiac trauma,”

AND

due

mt.

trauma,”

Ann. H.

jury 1940.

of

10

OsBoRNE, cidents,”

11

DOLARA,

heart injury

of

in

disease,” the

heart.

forty-two injury,” Am.

cases Heart W.

BARTHOLOMAE,

JR.:

to non-penetrating Med., 52:4, 1960.

M.: bodily

0.

the

mt.

D.: heart,”

G. R.: Lancet,

Med.,

46:485,

“Direct

lest.

Med.,

“Findings in 2:277, 1943. Pozzl,

LACTIC

1957.

non-penetrating

Ann.

L.:

conduction trauma,”

262

in-

14:653, fatal

ac-

“Atrioventricular defect followIn press.

DEHYDROGENASE

OF

PAM

Diseases of the Chest

PALONI

12

LEPESCHKIN,

13

DOLARA,

(Vol. 1951.

E.: Williams

I),

Modern and

ISOENZYMES

PULMONARY

The value of pulmonary arteriography in the diagnosis of pulmonary embolism will be enhanced if sources of error are recognized. The vascular changes in mitral stenosis with pulmonary hypertension and other conditions of post-capillary hypertension which the author calls “mitral lung” are characterized by narrowing of the vessels to, and underperfusion of, the lower zones. Narrowed vessels, pruning, underperfusion and oligemia are otherwise secondary signs of embolism. In the mitral lung, they lose their diagnostic validity. One has to fall back upon the direct

Electrocardiography Wilkins, Baltimore,

A.: “La comunicazione interventricolare da rottura isolata del setto nei traurni contusivi del cuore,” Minerva Med. Leg., 84:110, 1964. 14 KATZ, L. N. AND PIcK, A.: Clinical Electrocardiography. Part 1. The arrhythmia:, Lea and Febiger, London, 1956. 15 SIGLER, L. H.: “Abnormalities in the electrocardiogram induced by emotional strain,” Am. J. Cardiol., 8:807, 1961. 16 DEMUTi, W. E., Ja. AND SMITH, J. M.: “Pulmonary contusion,” Am. J. Surg., 109:819, 1965. 17 HARRIS, P., FRITTS, H. W., Ja. AND C0URSAND, A.: “Some circulatory effects of 5-Hy. droxytryptamine in man,” Circulation, 21:1134, 1960. 18 REID, J. M. AND BAIRD, W. L. M.: “Crushed chest injury: some physiological disturbance, and their correction,” Brit. Med. J., 1:1105, 1965. 19 KATZ, L. N.: Electrocardiography, Lea and Febiger, Philadelphia, 1946. For reprints, please write: of S. M. Nuova, Florence,

Serum lactic dehydrogenase isoenzyme studies have been made on 48 patients with hypothyroidism. In 17 (35 per cent), the isoenzyme distribution pattern resembled that of acute myocardial infarction with differential accentuation of LDH-1 and LDH-2 isoenzyme activity. It is suggested that this evidence of myocardial damage represents a specific form of cardiomyopathy resulting from chronic thyroid deficiency. Re-establishment of a euthyroid status with hormone therapy was accompanied by gradual disap-

ANGIOGRAPHY

AND

115:

LASKY,

A. AND intraventricular non-penetrating

SERUM

F.,

Med.,

J. 3., DULKIN, S. I. E.: “Serum glutamic-oxtransaminase activity in conditions aswith myocardial infarction. I. Bodily

3.,

LEINOFF,

and ing

H.

LOBSTEIN,

alacetic sociated 9

J.

H.

lest.

“Traumatic 1952.

H.: “Traumatic of its occurrence accidental bodily 1945. injury Ann.

8 LIEBERMAN, AND

W.: 6:421,

ZINSSER,

Arch.

MORANDO

IN

MYXEDEMA

Dr. Dolara, Italy.

HEART

Arcispedale

DISEASE

pearance of the “heart” iso e nz y me distribution. ECG improvement, and reduction in heart size. Serial LDH isoenzyme studies provided considerable help in the management of those patients with coronary artery disease and hypothyroidism in whom too rapid or excessive treatment may provoke myocardiai infarction. Assa, C. P., NoBLE, R. L.. THoMPsoN, E. W.: “Serum lactic dehydrogenase edema heart disease’,” Brit. Heart J.,

EMBOLISM

IN

“MITRAL

G. S. AND JONEs, isocozymes in ‘myx 28:663, 1966.

LUNG”

signs, the intraluminai filling defect, gross cut-off. or localized asymmetrical pruning. This limits the value of the method to some degree and with proper precaution leads to under-reading or “false negatives.” Pertinent precaution should be exercised in the diagnosis of pulmonary embolism in the mitral lung, both in the use of lung scanning with radioactive macro-aggregated albumin and In the plain roentgenogram. FLEISCUNER, embolism in

P. G.: “Angiographic the ‘mitrai lung’.”

diagnosis Radiology,

of pulmonary 87:705, 1966.