Urine volume and urinary sodium excretion during water diuresis

Urine volume and urinary sodium excretion during water diuresis

Southern Society for Clinical Research U KEA SYNTHESIS IN THE NEPHREC-TOMIZEDRAT. A METHOD FOR ‘THE STUDY OF RAPID CHANGES IN PROTEIN METABOLISM L. EN...

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Southern Society for Clinical Research U KEA SYNTHESIS IN THE NEPHREC-TOMIZEDRAT. A METHOD FOR ‘THE STUDY OF RAPID CHANGES IN PROTEIN METABOLISM L. EN(:EL,

ICRANK

in alpha

and MILDRED

There has

been

increasing

various

endocrines

Much

to

balance

during

metabolism.

overall

nitrogen

but there are many gaps in our knowl-

edge of the protein time

interest

about

relationship

stimuli

and

inhibition The

metabolism between

the

responses

of protein

present

and the exact

various in

types

of

acceleration

or

catabolism.

report

presents

an

improved

method for the study of rapid changes in protein metabolism

in rats by which

detect changes ment

of urea

phrectomized the

one is enabled

It is based on the measure-

nitrogen rats.

availability

accumulation

Its validity

of an

method for the determination the equal total

distribution

body

water,

tively constant during

a reasonable criteria

have

experimental

analyzing

periences

with

mixtures,

adrenal

period been

periods

and (4) a rela-

after nephrectomy. Data

the method,

of hemorrhages

cortical

will

be

and some ex-

the use of various extract

electrophoretic

amino

acid

and the effects

and shock will be considered.

No increase in

the

PLASMA PROTEINS IN CONTROL AND INJURED DOGS, GOATS AND RATS From

CHANUTIN,

M.D.

the

Biochemical Laboratory, University of Virginia, Charlottesville, Va. (This work was done undercontractwith the Medical

Division,C. W.S.)

This laboratory

has been engaged

in the frac-

tionation of serum of control and injured animals. The serum and fractions have been studied by electrophoretic AMERICAN

and chemical

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MEDICINE

goat.

in albumin

Four

were

concentrations.

was demonstrated

electrophoretically

pure

have been isolated. of whole plasma

comparatively until

in the serum of

in the beta globu-

in lipoproteins

The proteins they

little

change

of rats showed

electrophoretically

were separated

into four fractions.

After injury, marked increases were noted in the alpha

and

albumin

beta

globulins

and

a decrease

in

concentrations.

URINE

VOLUME

EXCRETION

AND URINARY

DURING WATER

A. J. CRUTCHFIELD,

From

SODIUM

DIURESIS

M.D. (by invitation)

and J. EDWIN WOOD, JR.,

M.D.

the Department of Medicine, University Virginia Medical School, Charlottesville, Va.

The

influence

sodium failure.

of ,water diuresis

excretion

individuals

in normal

with congestive

total renal

excretion

and urine has been determined

of

on urinary

has been observed

and patients

Hourly

heart

of sodium

for six consecu-

tive hours following

the ingestion

water. This pattern

of sodium and water excre-

of one liter of

tion was studied following:

(1) plain water and

(2) plain water plus certain

diuretic

appropriately water

ALFRED

by a

or turpentine

by an increase

lins and a decrease

proteins

changes

by mustard

characterized

the

changes in body

met.

in

isolated from

and some were characterized

injured

sensitive

rate of rise of blood urea nitrogen

These

presented

ne-

throughout

are unlikely

The goats

on (1)

of blood urea, (2)

short enough so that significant water composition

and

of urea (3)

in

depends

accurate

and a decrease

Fractions

to

in three hours or less with a high

degree of accuracy.

heat,

increases

high lipide content.

of illness, injury and

nitrogen

has been learned

concentrations.

trol animals

G.

the Department of Medicine, Emory University School of Medicine, Atlanta, Ga.

recent years in the relation

showed

these sera were not present in the serum of con-

M.D. (by invitation)

ENGEL,

by mustard,

injections

and beta globulins

albumin

M.D., E. IRENE PENTZ,

h1.D. (by invitation) From

The serum of dogs injured cold or turpentine

preceded

controls.

Sodium

made by the photometric of which

has been

submitted

summary.

periments From

in each

substances,

case by plain

determinations method,

discussed

were

the accuracy

in a previously

Altogether

eighty-six

ex-

have been done on forty patients. these experiments

a definite

pattern

of

sodium and water excretion has been recorded. This pattern is essentially the same in outline for both

normal

and

congestive

tients, though quantitatively

heart

failure

pa-

different.

Mercupurine and intravenous aminophyllin regularly produced a disproportionate increase

Southern

508 in urine

volume

and

favor

of the latter.

mary

renal

total

This

action

Society for Clinical

urinary

suggests

sodium

that

of these substances

depression

of tubular

Xanthines

by mouth

much

less powerful

under

the

duced

no significant

reabsorption have effect.

conditions

in

the primay

be

of sodium.

normal

fluorescein. results

(range

average

using riboflavin

substances

fourteen

gave

circulation

though

with age, the shortest

glucose

being six seconds in an infant.

and

pro-

effect on urine volume

or

were determined long

(arm

tree among it would appear

water diuresis does not increase

urinary

but may actually

that

sodium

depress it.

FLUORESCENT TRACER SUBSTANCES IN THE DETERMINATIONOF CIRCULATION TIMES IN MAN

congestive segments

(arm

segments

normal

individuals

times

to arm)

of the

and

vascular

and those with

failure.

Times obtained from long were a more sensitive index of circu-

shorter

segments.

than

times

Circulation

arterial

segment

the difference

obtained times

over

through

a

was determined

between

(greater

by

arm to arm and

arm to foot times. In some instances time was abnormal

WILLIAM ADOLPH, M.D., TRAVIS WINSOR,

arm to arm time

to foot)

retardation

taking

seconds,

times varied

Circulation

over short

latory systemic

normal

and

comparable

to twenty-six

19). Riboflavin

a similar,

of this experiment

From these observations

individuals

Both

Urea

sodium excretion.

elimination

among

Research

the segment

than twelve seconds

M.D., WALTER C. RALSTON,M.D. and

under

standard

GEORGEM. LEIBY, M.D. (introduced by

failure

when the arm to arm time was normal.

conditions)

in

patients

with

George E. Burch, M.D.) From the Medical Division, Birmingham General Hospital,Van Nuys, Calif. The purpose of the present presentation to demonstrate cent tracer

the use of riboflavin

substance,

value

and

(3)

measurements diovascular histamine

in various system.

The

technic

value

of

of the car-

was to raise a

one minute

into the antecubital from

in the periphery

riboflavin

of the injection

of yellow-green of the wheal

ultraviolet

light.

was

vein. The time was

the beginning

to the appearance filtered

the

segments

fluorescence

detected

Normal

using

individuals

Celiac

ganglionectomy

formed

during

rotomy

in four

dyskinesia. only. Celiac

in vivo and in vitro. Riboflavin

and fluorescein

were readily diffusible

in tissue spaces and easily visible

giving sharp

with so-called

gangionectomy

perlapa-

biliary

was employed

pancreatitis

ganglionectomy

vagotomy

has been

of exploratory

had right splanchnicectomy

pain from recurring

and

were performed

concerning

were the most innocuous,

patients

Another

Celiac

alone

the course

and patients with congestive failure were studied. were studied

OR SYMPATHECTOMY

From the Departmentof Surgery, Duke University Schoolof Medicine,Durham,N. C.

A number

materials

AND

KEITH S. GRIMSON,M.D.

severe functional

of fluorescent

IN PATIENTS UNDER-

GANGLIONECTOMY

VAGOTOMY

a technic

wheal on various portions of the body.

measured

PAIN PATHWAYS GOING CELIAC

time of greater clinical

to demonstrate

After approximately injected

as a fluores-

(2) to present

which renders circulation

is (1)

OBSERVATIONS ON ABDOMINAL VISCERAL

the effect

subdiaphragmatic

in two patients

abdominal

for

in one patient. with

pain. Observations

of these

operations

and

also concerning

visceral pain after transthoracic

vagotomy

peptic

for

chnicectomy

during

ulcer

and

after

sympathectomy

splan-

for hyper-

end points in a darkened room. Peak fluorescence for riboflavin occurred in dilutions ten

tension will be presented.

times

carry visceral afferent pain pathways and that the splanchnic nerves do. A major portion of

greater

than

for fluorescein.

Maximum

fluorescence was more intense with fluorescein. Optimum dose for riboflavin in vivo was 0.8 mg. per kilo.

Arm

to arm

times

were determined

It is concluded

that the vagus nerves do not

the splanchnic

visceral

travel through

the celiac

AMERICAN

afferent

pain pathways

ganglia.

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